1. Measurement of salivary metanephrines is just as accurate as plasma metanephrines in detecting a pheochromocytoma or sympathetic paraganglioma. 2. Anxiety levels are elevated in patients with a pheochromocytoma or sympathetic paraganglioma
ID
Bron
Verkorte titel
Aandoening
Pheochromocytoma, paraganglioma, diagnosis, metanephrines
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The diagnostic accuracy (sensitivity and specificity) of salivary levels of metanephrines
Doel van het onderzoek
1. Measurement of salivary metanephrines is just as accurate as plasma metanephrines in detecting a pheochromocytoma or sympathetic paraganglioma.
2. Anxiety levels are elevated in patients with a pheochromocytoma or sympathetic paraganglioma
Onderzoeksopzet
Not applicable
Onderzoeksproduct en/of interventie
Collecting saliva and collecting 20 ml blood.
Filling out a anxiety questionnaire
Algemeen / deelnemers
[default]
The Netherlands
Wetenschappers
[default]
The Netherlands
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Patients (age > 18 years) with a pheochromocytoma or sympathetic paraganglioma, with elevated plasma metanephrines AND
Germline mutation carriers without elevated plasma metanephrines AND
Healthy subjects
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
The need to use medication known to influence plasma metanephrines concentration: tricyclic antidepressants, phenoxybenzamine, MAO-inhibitors, sympathomimetics, cocaine, methyldopa
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4962 |
| NTR-old | NTR5066 |
| CCMO | NL50957.042.14 |
| OMON | NL-OMON43844 |