Monitoring a patient’s oxygen status during anesthesia using pulse oximetry is essential. The new Oxygen Reserve Index (ORI) may help provide clinicians real-time visibility to oxygenation in a moderate hypoxic range and serve as a warning of an…
ID
Bron
Aandoening
Oxygen Reserve Index
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Validation of the new Oxygen Reserve Index (ORI) by collecting optical data using the Rainbow SET Pulse CO-Oximeter (Masimo Corp.) and comparing them to whole blood references of arterial and venous blood drawn in healthy volunteers
Doel van het onderzoek
Monitoring a patient’s oxygen status during anesthesia using pulse oximetry is essential. The new Oxygen Reserve Index (ORI) may help provide clinicians real-time visibility to oxygenation in a moderate hypoxic range and serve as a warning of an impending hypoxic state. In this way, ORI may enable proactive interventions to avoid hypoxia.
Onderzoeksopzet
during 4 hours
Onderzoeksproduct en/of interventie
•Change in inspiratory oxygen fraction (FiO2):
•Normoxia: room air (FiO2 0.21) (baseline)
•Hyperoxia: 21% to 100% oxygen (FiO2 0.21 to 1.0)
•Hypoxia: breathing mixtures of N2 in air via a tight fitting facemask to reach arterial oxygen saturation levels of 90%, 80%, and eventually 70% as measured by pulse oximetry (Radical 7, Masimo Corp.)
•Change in expiratory carbon dioxide concentration (etCO2) (during normoxia, awake state):
•Normoventilation (etCO2 4.5 – 5 Vol%)
•Partial rebreathing or adding external medical CO2 (target etCO2 7 – 7.5 Vol%)
•Hyperventilation (target etCO2 2.5 – 3 Vol%)
Algemeen / deelnemers
Wetenschappers
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• Age between 18 and 45 years
• Written informed consent
• Healthy subjects
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• Pregnant women (female subjects will have a pregnancy test prior to being admitted to the study).
• Presence of any cardiovascular or pulmonary disease
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4943 |
| NTR-old | NTR5047 |
| Ander register | : ORI-001 |