The primary objective of this study is to evaluate changes in oral health during a 4-month naval mission and once one month thereafter.
ID
Bron
Verkorte titel
Aandoening
Microbiome shifts, Mucosal inflammation, Periodontal health, Gingival inflammation, Stress, Oral parafunctions
Ondersteuning
Gustav Mahlerlaan 3004
1081 LA Amsterdam, NL
+31 (0)20 5188888
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The main study parameter and indicator of oral health is bleeding of the gingiva on probing (BOP; gingival inflammation).
Achtergrond van het onderzoek
Rationale: Oral health problems are a major concern for military personnel, especially when deployed in remote regions of the world. Prior to taking part in a mission, military personnel is required to meet certain standards in oral health status, as outlined in the NATO issued dental fitness protocol. Nevertheless, military dentists frequently report mucosal inflammation (oral ulcers), fungal oral infections and gingival bleeding among personnel during a mission. In scientific literature, also reports can be found of non-military expeditions, reporting increased gingival bleeding, and oral ulcers. It has been suggested that stress, changes in diet and lifestyle along with reduced levels of personal care during mission can lead to deterioration of oral health status, but scientific data about the causes are largely lacking. In addition, it has also been reported that the composition of the oral microbial community is predictive for the development of oral disease under stress.
Objective: The primary objective of this study is to monitor changes in oral health during a 4-month naval mission and once approxemately one month thereafter. The secondary objectives are to correlate possible changes compared to the baseline measurements to lifestyle, diet and stress. Finally, to assess whether microbiome composition can predict changes in oral health or general health.
Study design: prospective observational cohort study
Nature and extent of the burden and risks associated with participation, benefit and group relatedness: the burden exists of seven site visits of about 30 minutes. Examinations are non-invasive and do not cause physical discomfort. The subjects will complete one questionnaire per visit, with questions regarding general health, sleep, stress, physical activity, food intake and disorders of the temporomandibular joint. Participation does not benefit the subjects. The risks are negligible. The study is group-related because the research questions can only be answered in a cohort where food, circadian rhythm and stress from the mission assignment are controlled.
Doel van het onderzoek
The primary objective of this study is to evaluate changes in oral health during a 4-month naval mission and once one month thereafter.
Onderzoeksopzet
Visit 1 – within the first two weeks of the mission (baseline)
Visit 2 to 4 – every 2 to 3 weeks (average 2.5 weeks) during the mission
Visit 5 – within the last two weeks of the mission (end of mission visit)
Visit 6 – within 9 weeks (± 3 weeks) after the end of the mission
Onderzoeksproduct en/of interventie
This is an observational study, without any interventions.
Algemeen / deelnemers
C.M.C. Volgenant
Academisch Centrum Tandheelkunde Amsterdam, Department of Oral Health Science
Gustav Mahlerlaan 3004
Amsterdam 1081 LA
The Netherlands
+31205980596
c.volgenant@acta.nl
Wetenschappers
C.M.C. Volgenant
Academisch Centrum Tandheelkunde Amsterdam, Department of Oral Health Science
Gustav Mahlerlaan 3004
Amsterdam 1081 LA
The Netherlands
+31205980596
c.volgenant@acta.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
All Dutch service members participating are declared fit to participate in the naval mission, every service member of the mission is a potential subject. Only with written informed consent a potential subject can participate in this study.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
A potential subject that meets any of the following criteria is to be excluded from participation in this study:
- carrier of removable partial dentures
- carrier of a removable night guard
- use of antibiotics three months prior to the mission
- use of anti-inflammatory drugs on a regular basis (NSAIDs)
- adverse medical history or long-term medication
- prescribed medication (except for contraceptives)
Opzet
Deelname
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In overige registers
Register | ID |
---|---|
NTR-new | NL6430 |
NTR-old | NTR6608 |
CCMO | NL62301.048.17 |
OMON | NL-OMON44394 |