Primary Objective: 1) To examine how the brain regions and responses involved in the appraisal of ambiguous affective stimuli differ between anorexia nervosa patients and healthy control participants. Secondary Objective(s): To assess how…
ID
Bron
Verkorte titel
Aandoening
Anorexia Nervosa, emotion processing, fMRI, brain, ambiguity.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Upon ambiguous affective stimuli, different brain regions in Anorexia nervosa patients will be activated with different responses compared tot healthy controls.
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
Primary Objective:
1) To examine how the brain regions and responses involved in the appraisal of ambiguous affective stimuli differ between anorexia nervosa patients and healthy control participants.
Secondary Objective(s):
To assess how anorexia nervosa patients differ from healthy control participants in terms of: 1) emotion processing, 2) the effects of processing ambiguous affective stimuli on levels of (negative) emotions, 3) the association between measures of emotion processing and emotional and neural responses to ambiguous affective stimuli.
Onderzoeksopzet
once
Onderzoeksproduct en/of interventie
Not applicable.
Algemeen / deelnemers
Wenshoek 4
Lot Sternheim
Zeist 3705 WE
The Netherlands
+31 (0)30 6965431
l.sternheim@altrecht.nl
Wetenschappers
Wenshoek 4
Lot Sternheim
Zeist 3705 WE
The Netherlands
+31 (0)30 6965431
l.sternheim@altrecht.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Anorexia nervosa participants:
-Diagnosed with AN of ED-NOS-AN (DSM-IV criteria) of ANR (DSM-5 criteria)
-Right-handed
-Female
-Age between 18 and 35 years of age at the day of screening
-BMI below 17.5 kg/m2
-Having written informed consent
-Willing to comply with the study procedures
-Willing to accept use of all anonymized data, including publication, and the confidential use and storage of all data.
-Willing to receive information about chance findings of pathology and approving of the disclosure of this information to the general physician.
Healthy control participants:
-Right-handed
-Female
-Age between 18 and 35 years of age at the day of screening
-Having given written informed consent
-Willing to comply with the study procedures
-Willing to accept use of all anonymized data, including publication, and the confidential use and storage of all data
-Willing to receive information about chance findings of pathology
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Anorexia nervosa participants:
-Having a history of or current excessive alcohol consumption (> 28 units per week)
-Having a drug dependency.
-Not having a general practitioner
-Participation in any other clinical trial in the week preceding this study
-Contra-indications to MRI scanning on the basis of the MRI screening form, including:
- Claustrophobia
- Metal objects in the body incompatible with MRI scanning
-Having a history of medical or surgical events that may significantly affect the study outcome, such as brain surgery.
-Working at the group Experimental Psychopathology of the Department of Social Sciences of the Utrecht University, the Image Sciences Institute or the Radiology Department of the UMC Utrecht or Altrecht Eating Disorders Rintveld as employee or student.
Healthy control participants:
-A current or lifetime psychiatric disorder
-Having a history of or current excessive alcohol consumption (> 28 units per week)
-Having a drug dependency.
-Participation in any other clinical trial in the week preceding this study
-Contra-indications to MRI scanning on the basis of the MRI screening form, including:
- Claustrophobia
- Metal objects in the body incompatible with MRI scanning
-Having a history of medical or surgical events that may significantly affect the study outcome, such as brain surgery.
-Working at the group Experimental Psychopathology of the Department of Social Sciences of the Utrecht University, the Image Sciences Institute or the Radiology Department of the UMC Utrecht or Altrecht Eating Disorders Rintveld as employee or student.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4199 |
| NTR-old | NTR4351 |
| CCMO | NL45093.041.13 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| OMON | NL-OMON38444 |