Effect of duration of procedural sedation on postprocedural respiration

Background Procedural sedation is used to enable patients to tolerate uncomfortable or painful diagnostic or therapeutic, non-surgical procedures. Practitioners use medication for PSA that can cause cardiorespiratory compromise. A well known side effect of sedatives and opioids is depression of the respiratory system. Hypothetically this depression can result in atelectasis formation and/or respiratory problems, especially if the procedure is protracted. No evidence is available concerning the relationship between the duration of procedural sedation and the formation of atelectasis and/or respiratory symptoms. This study investigates this relationship via a non-invasive method using only proprietary procedures for PSA and a short, 5 question telephonical questionnaire.
• Main research question
Is longer duration of procedures under PSA associated with an increased incidence of atelectasis formation and/or respiratory symptoms
• Design (including population, confounders/outcomes)
Prospective non-randomized trial. Population: patients scheduled for a procedure under PSA with the potential to have a procedure duration of more than 2 hours. Exclusion criteria: previous lung surgery, ASA status 4, COPD GOLD class III or IV, SpO2 on room air (pre-procedural) of <97%. Confounders: obesity, airway compromise, need for an FiO2 of more than 50% during the procedure.
• Expected results
null-hypothesis: There is no relationship between the duration of the procedure under PSA and the incidence of atelectasis and/or respiratory symptoms.

There is no relationship between the duration of the procedure under PSA and the incidence of atelectasis and/or respiratory symptoms.

Post-procedural sedation and 7 days post sedation procedure