Screening of esophageal cancer can be improved by the optical detection of field cancerization
ID
Bron
Verkorte titel
Aandoening
Barrett's esophagus, esophageal cancer, field cancerization
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The primary objective of our study is to evaluate the feasibility of using MDSFR combined with OCT for the detection of field cancerization in Barrett esophagus patients.
Achtergrond van het onderzoek
Barrett's esophagus (BE) is a precursor lesion for esophageal adenocarcinoma. Therefore, the current Barrett's surveillance protocol consists of white light endoscopy and random biopsies. Field cancerization is based on the concept that focal cancers arise in tissue areas with random genetic changes. Light scattering spectroscopy might be able to detect this field cancerization and therefore be an innovative approach to improve detection of prevalent neoplasia in BE patients.
In this study, we will evaluate the feasibility of optical detection of field cancerization in BE patients.
Doel van het onderzoek
Screening of esophageal cancer can be improved by the optical detection of field cancerization
Onderzoeksopzet
not applicable
Onderzoeksproduct en/of interventie
Optical measurements will be performed on several locations in the esophagus. Biopsies will also be obtained. Brush cytology will be obtained.
Algemeen / deelnemers
Bldg. C2-210, Meibergdreef
J.J.G.H.M. Bergman
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5669111
j.j.bergman@amc.uva.nl
Wetenschappers
Bldg. C2-210, Meibergdreef
J.J.G.H.M. Bergman
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5669111
j.j.bergman@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Age > 18 years.
- Known BE, defined as columnar lined epithelium of the esophagus containing intestinal metaplasia upon biopsy.
- Signed informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Contraindications for ER and/or obtain biopsies (e.g. due to anticoagulation, coagulation disorders, esophageal varices).
- Presence of an advanced lesion (e.g. type 0-I or type 0-III) not amendable for endoscopic resection (T1b).
- Presence of erosive esophagitis (Los Angeles classification ¡ÝA).
- Unable to provide signed informed consent.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5628 |
| NTR-old | NTR5735 |
| Ander register | AMC METC 2015_323 : AMC METC 2015_323 |