Intensive vascular care, aimed at secundary prevention of cerebrovascular disease, is efficacious in patients with Alzheimer's disease that have vascular lesions on MRI.
ID
Bron
Verkorte titel
Aandoening
Alzheimer's disease
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Change in impairments after two years of follow up in activities of daily living as measured by the Interview for Deterioration in Daily life in dementia (IDDD).
Achtergrond van het onderzoek
Frequently patients with a clinical diagnosis of Alzheimer's disease also harbour cerebrovascular lesions on neuroimaging. It is not clear to what extent these lesions contribute to (1) functional impairments, and (2) the prognosis of these patients. In this open multicentre clinical trial the hypothesis is tested that intensive vascular care is efficacious in these patients, resulting in slower deterioration after a follow up of two yeras in patients receiving such care, in comparison to patients receiving standard care.
Doel van het onderzoek
Intensive vascular care, aimed at secundary prevention of cerebrovascular disease, is efficacious in patients with Alzheimer's disease that have vascular lesions on MRI.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
Multicomponent intervention consisting of a combination of measures aimed at prevention of cerebrovascular disease (platelet aggregation inhibitors, statin, strict regulation of blood pressure, diabetes, life style interventions concerning smoking, body weight, excercise). Patients in the control group will recieve 'regular care' i.e. less frequent visits, without specific attention to vascular risk factors.
Algemeen / deelnemers
P.O. Box 22660
W.A. Gool, van
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5664044
w.a.vangool@amc.uva.nl
Wetenschappers
P.O. Box 22660
W.A. Gool, van
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5664044
w.a.vangool@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Patients with early Alzheimer's disease according to clinical criteria, that have on MRI either cerebral infarcts or significant white matter abnormalities.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Severe dementia;
2. Limited life expectancy.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL590 |
| NTR-old | NTR646 |
| Ander register | : N/A |
| ISRCTN | ISRCTN74902933 |