The aims of the study are: 1. to assess the clinical utility and feasibility of AFI surveillance colonoscopy in patients with intermediate or high risk for adenomatous polyps; 2. to determine the additional value of AFI in the detection of…
ID
Bron
Verkorte titel
Aandoening
Patients with an increased risk for polyps or cancer
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The sensitivity of high resolution white light endoscopy will be compared to that of AFI for detection of polyps and cancer in the colon.
Achtergrond van het onderzoek
An endoscopic video autofluorescence imaging study for detection of Adenomatous Polyps of the colon with patients ad an intermediate and high risk of adenomatous polyps.
Doel van het onderzoek
The aims of the study are:
1. to assess the clinical utility and feasibility of AFI surveillance colonoscopy in patients with intermediate or high risk for adenomatous polyps;
2. to determine the additional value of AFI in the detection of polyps in these patients;
3. to characterize the pit-patterns in the different polyps using NBI.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
High resolution white light endoscopy versus Autofluorescence endoscopy.
Algemeen / deelnemers
Department of Gastroenterology and Hepatology <br>
P.O. Box 22660
Evelien Dekker
Meibergdreef 9
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5664702
e.dekker@amc.uva.nl
Wetenschappers
Department of Gastroenterology and Hepatology <br>
P.O. Box 22660
Evelien Dekker
Meibergdreef 9
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5664702
e.dekker@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Previous adenomatous polyp (polyp-surveillance);
2. Previous adenocarcinoma of the colon for which a partial colectomy was performed;
3. Hereditary non-polyposis colorectal cancer (either genetically proven by a mutation in one of the mismatch repair genes or with a clinical diagnosis according to the Amsterdam II criteria [14]);
4. Positive family history for CRC: a first-degree family-member fullfills one of the revised Bethesda criteria.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Familiar adenomatous polyposis;
2. History of inflammatory bowel disease;
3. Severe coagulopathy;
4. Age less than 18 years.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
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Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL479 |
| NTR-old | NTR521 |
| Ander register | : N/A |
| ISRCTN | ISRCTN76121851 |