A systems biology approach is an hypothesis free study that looks at multiple layers within one patient (genome, epigenome, proteome, metabolome)
ID
Bron
Aandoening
(non-infectious) ocular inflammation, uveitis, age related macular degeneration, inflammatory corneal disease, idiopathic inflammatory orbital disease
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
We aim to employ an "omics"-driven systems biology approach on patients with ocular inflammation in order to identify the molecular pathways underlying the pathogenesis of ocular and orbital inflammation and develop clinically usefull markers to predict disease outcome and treatment responses (eg biomarkers). For this we study multiple layers of the immune system (genome, epigenome, proteome, metabolome and cellsubsets).
Doel van het onderzoek
A systems biology approach is an hypothesis free study that looks at multiple layers within one patient (genome, epigenome, proteome, metabolome)
Onderzoeksopzet
Venous blood is drawn at active inflammation
Onderzoeksproduct en/of interventie
none (observational)
Algemeen / deelnemers
University Medical Centre Utrecht
Jonas Kuiper
Heidelberglaan 100 3584 CX Utrecht
Utrecht
The Netherlands
+31 (0)88 7553569
j.j.w.kuiper@umcutrecht.nl
Wetenschappers
University Medical Centre Utrecht
Jonas Kuiper
Heidelberglaan 100 3584 CX Utrecht
Utrecht
The Netherlands
+31 (0)88 7553569
j.j.w.kuiper@umcutrecht.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- 18-95 years of age
- diagnosed with non-infectious uveitis (anterior, intermediate, posterior, panuveitis, scleritis) OR
- inflammatory corneal disease (keratokonus, Fuchs endothelial corneal dystrophy) OR
- idiopathic inflammatory orbital disease OR
- age-related macular degeneration
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- (acquired) immune deficiencies
- inadequate knowledge of Dutch
- current use of systemic immunomodulatory agents, biologicals or cyclosporine
- IV corticosteroids in last 14 days before inclusion
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4512 |
| NTR-old | NTR4630 |
| Ander register | ABR: NL46874.041.13 : METC: 14/065 |