Transcutaneous blood gas measurements can be used to detect neonatal sepsis.
ID
Bron
Verkorte titel
Aandoening
Neonatal late-onset sepsis
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The relation between transcutaneous blood gas levels and neonatal sepsis.
Achtergrond van het onderzoek
Neonatal sepsis is one of the major causes of death in premature neonates. Research has shown that the microcirculation could potentially be an indicator of sepsis, even in an early phase. During sepsis the microcirculation gets shunted from the arterioles to the venules, leaving the microcirculation hypoxemic and hypercarbic. These deviating oxygen and carbon dioxide levels during sepsis could potentially be measured with transcutaneous blood gas monitoring.
Doel van het onderzoek
Transcutaneous blood gas measurements can be used to detect neonatal sepsis.
Onderzoeksopzet
In this study, a standard of care heated transcutaneous sensor and an unheated transcutaneous sensor, are used to perform continuous measurements for 2 weeks. If sepsis occurs within these
2 weeks without recovery during these 2 weeks, the measurement is prolonged until clinical recovery has occurred as indicated by the cessation of antibiotic treatment for sepsis.
Onderzoeksproduct en/of interventie
N/A
Algemeen / deelnemers
Wetenschappers
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
A gestational age of 24 weeks up to and including 31 weeks at the time of inclusion.
A pulse oximeter as part of regular care.
Written informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
A gestational age of 32 weeks or more at the time of inclusion.
Skin condition contraindicating transcutaneous measurements.
Absence of written informed consent.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL9778 |
| Ander register | METC Erasmus MC : MEC-2020-0626 |