We hypothesize that age-associated changes of immune function contribute to impaired anti-melanoma immunity and that these changes underlie the higher incidence and the more aggressive behaviour of melanoma in the elderly. We think that the…
ID
Bron
Verkorte titel
Aandoening
Metastatic melanoma.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
To study the frequencies and differentiation status of CD4 and CD8 T cell populations (Tnaive, TCM, TEM, TEMRA) in young (18-50) and old (> 65) treatment naive metastasized melanoma patients at baseline. In addition, the frequencies and differentiation of Treg in these two age groups will be assessed. We compare this with data from two age-matched groups healthy controls to distinguish age-factors from melanoma-factors.
Doel van het onderzoek
We hypothesize that age-associated changes of immune function contribute to impaired anti-melanoma immunity and that these changes underlie the higher incidence and the more aggressive behaviour of melanoma in the elderly.
We think that the baseline characteristics in treatment naive metastasized melanoma patients show a more senescent immune system as compared to two age-matched groups healthy controls.
Onderzoeksproduct en/of interventie
none
Algemeen / deelnemers
Hanzeplein 1
R.R.H. Brom, van den
Groningen 9700 RB
The Netherlands
0031503616161
r.r.h.van.den.brom@umcg.nl
Wetenschappers
Hanzeplein 1
R.R.H. Brom, van den
Groningen 9700 RB
The Netherlands
0031503616161
r.r.h.van.den.brom@umcg.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Pathologically proven melanoma, metastasized
2. No prior systemic anti-tumour treatment
3. Being able to give informed consent (time to consider study participation is minimal three days)
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Without pathologically proven melanoma
2. Treated with immune-modulating drugs
3. Concomitant chronic diseases that may affect immune system (such as prior or current malignant disease, active infectious disease, rheumatologic diseases, kidney diseases, active allergy etc.)
4. No informed consent
5. Severe anaemia defined as a Hb of less than 6,0 g/dL
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4319 |
| NTR-old | NTR4539 |
| Ander register | : METc 2011.388 |