Usage of SDD or SOD has been shown to reduce the incidence of ventilator associated pneumonia (VAP) and to improve patient survival. SDD and SOD were shown not to increase resistance of bacteria colonizing the digestive tract. It can not be…
ID
Bron
Verkorte titel
Aandoening
Antibiotic resistance, Selective Decontamination of the Digestive tract (SDD), Selective Oropharyngeal Decontamination (SOD), Intensive Care Unit (ICU)
Ondersteuning
Postbus 9600, 2300 RC Leiden
The Netherlands
Postbus 9600, 2300 RC Leiden
The Netherlands
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Rectal colonization with any resistant aerobic Gram-negative bacteria at any time point within 10 days after ICU discharge.
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
Usage of SDD or SOD has been shown to reduce the incidence of ventilator associated pneumonia (VAP) and to improve patient survival.
SDD and SOD were shown not to increase resistance of bacteria colonizing the digestive tract. It can not be excluded that antibiotics in the faeces suppress the growth of resistant bacteria during SDD, and that those resistant strains may quickly re-emerge after discontinuation of SDD. The rate of re-colonization with resistant enteral bacterial flora after cessation of SDD or SOD is currently unknown.
To determine factors associated with emergence and persistence of pathogenic Gram-negative bacteria and to assess the rate of return of resistant enteral bacterial flora after treatment with SDD or SOD a follow-up study will be performed of rectal cultures of patients after discharge from the ICU at determined intervals.
Onderzoeksopzet
Days 0, 3, 6 and 10 after discharge form the ICU.
Onderzoeksproduct en/of interventie
Rectal cultures after usage of either Selective Decontamination of the Digestive tract (SDD) or Selective Oropharyngeal Decontamination (SOD).
Algemeen / deelnemers
Leiden University Medical Center<br>
Postbus 9600
E.H.R. Essen, van
Leiden 2300 RC
The Netherlands
+31 (0)71 5268015
e.h.r.van_essen@lumc.nl
Wetenschappers
Leiden University Medical Center<br>
Postbus 9600
E.H.R. Essen, van
Leiden 2300 RC
The Netherlands
+31 (0)71 5268015
e.h.r.van_essen@lumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
All adult ICU patients treated with either SDD or SOD for more than 4 days (96hrs).
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Patients younger than 18 years of age;
2. Patients treated with enteral antibiotics other than SDD or SOD during ICU-stay.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL3167 |
| NTR-old | NTR3311 |
| Ander register | CME LUMC : 10 V006 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |