By comparing protein profiles of dysplastic vs non-dysplastic Barrett epithelium, a novel biomarker for prediction of early neoplasia may be identified.
ID
Bron
Aandoening
Barrett's esophagus, Barrett's neoplasia, Barrett's cancer, Barrett's dysplasia, proteomics
Ondersteuning
Erasmus Medical Center (EMC), department of Neurology
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Identification of peptides and proteins which could indicate presence of early neoplasia in a Barrett's esophagus.
Achtergrond van het onderzoek
The purpose of this project is to compare the protein profile of Barrett's mucosa with and without early neoplasia in ER specimens in epithelial and stromal cells aiming to identify a biomarker indicating presence of early neoplasia in BE.
Doel van het onderzoek
By comparing protein profiles of dysplastic vs non-dysplastic Barrett epithelium, a novel biomarker for prediction of early neoplasia may be identified.
Onderzoeksopzet
May-2012: Interim analysis of 5 dysplastic vs 5 non-dysplastic samples;
March-2013: Complete analysis of all obtained ER samples.
Onderzoeksproduct en/of interventie
Dysplastic group:
Non additional.
Non-dysplastic group:
Endoscopic resection (ER-cap technique) of non-dysplastic Barrett's esophagus.
Algemeen / deelnemers
Bldg. C2-210, Meibergdreef
J.J.G.H.M. Bergman
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5669111
j.j.bergman@amc.uva.nl
Wetenschappers
Bldg. C2-210, Meibergdreef
J.J.G.H.M. Bergman
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5669111
j.j.bergman@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Inclusion criteria ‘dysplastic’ group:
1. Scheduled ER for Barrett’s esophagus containing HGD or early cancer;
2. Review of biopsies and histopathology specimens by an expert local pathologist;
3. Written informed consent.
Inclusion criteria ‘non-dysplastic’ group:
1. Scheduled surveillance endoscopy for Barrett’s esophagus without dysplasia;
2. No dysplasia in biopsies, or biopsies ‘indefinite for dysplasia’ during at least the last two years;
3. No visible abnormalities in Barrett’s esophagus in the two most recent surveillance endoscopies;
4. Review of biopsies and histopathology specimens by an expert local pathologist;
5. Written informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Exclusion criteria ‘dysplastic’ group:
1. In case histopathological assessment of the frozen half of the ER specimen is necessary for clinical decision making, the specimen will be retrieved from the Barrett’s research tissue bank and further processed for clinical care.
Exclusion criteria ‘non-dysplastic’ group:
1. Patients that are not suitable candidates for ER because of co-morbidity.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL3095 |
| NTR-old | NTR3249 |
| Ander register | METC AMC : 11/096 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |