In the proposed study we will investigate the effect
ID
Bron
Verkorte titel
Aandoening
Stress-induced emotional interference and decrease of cognitive performance
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Emotional-interference: threat-interference during working memory performance (n-back task with emotional distracters), threat- and positive interference (Pictorial Emotional Stroop Task, self-report cognitive interference during cognitive performance (CIQ).<br>
Cognitive performance: working memory performance (n-back task), and executive cognitive performance (OSPAN task)
Achtergrond van het onderzoek
Background: Previous evidence suggests that large single doses of exogenous cortisol (hydrocortisone) have acute effects on cognitive processing of emotional stimuli.
However, such effects of hydrocortisone on cognitive performance under acute stress have never been tested even though this would be of considerable fundamental and eventually possibly practical importance. This should be investigated by assessing cognitive performance under stress and the influence of hydrocortisone administration.
Study design: A double-blind, placebo-controlled between-subjects experiment.
Study population: Eighty healthy female participants aged between 18 and 25 who will be recruited from Leiden University campus and online advertisements.
Intervention: Participants will receive either a placebo or 40 mg of hydrocortisone as capsules for oral intake, in the afternoon after limited dietary restrictions (no intake of nutrients 1.5 hour prior to drug/placebo administration).
Doel van het onderzoek
In the proposed study we will investigate the effect
Onderzoeksopzet
One timepoint: Participants come to the lab, complete the baseline measurements, take the medication (hydrocortisone or placebo), wait for an hour, and then do the rest of the tests.
Onderzoeksproduct en/of interventie
Intervention: single administration of 40 mg hydrocortisone capsule
Control condition: single administration of placebo capsule
Algemeen / deelnemers
Wassenaarseweg 52, PO Box 9555
Leiden 2300 RB
The Netherlands
+31715276457
a.angelidis@fsw.leidenuniv.nl
Wetenschappers
Wassenaarseweg 52, PO Box 9555
Leiden 2300 RB
The Netherlands
+31715276457
a.angelidis@fsw.leidenuniv.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- age between 18 and 25.
- females.
- Sufficient knowledge of the Dutch language.
- high trait cognitive test anxiety (CTAS score above the median out of an online local study with over 1000 responses).
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- use of prescription medication other oral contraceptives
- Treatment for psychiatric, endocrine or neurological (CNS) medical problems in the past or present.
- Use of corticosteroid medication (oral, nasal, injected) in the 6 months prior to enrollment or dermal corticosteroid medication in the week prior to enrollment.
- Regular smoking (more than 10 cigarettes per week) or any in the 12 hours prior to testing.
- Use of more than three alcoholic units per day.
- Frequent or recent use of cannabis (on average once a week or more frequent in the three months prior to enrollment or single use or more in the week prior to enrollment).
- Use of more than 3 units of alcohol in the last 24 hours, use of alcohol during the last 12 hours, or consumption of any other recreational drug in the last 24 hours prior to testing.
- Intensive physical cardiovascular sports training for more than 1 hour, at least 5 days a week.
- pregnancy
- lactation
- Raynaud syndrome
Opzet
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL6829 |
| NTR-old | NTR7066 |
| Ander register | ABR number: 62072 : LUMC METC file number: NL62072.058.17 |