Targeted Next Generation Sequencing (NGS) can distinguish benign pancreatic diseases, such as pancreatitis, from pancreatic malignancies during the diagnostic proces of patients with an uncertain diagnosis and treatment plan.
ID
Bron
Verkorte titel
Aandoening
Pancreatic Cancer
Periampullary Cancer
Pancreas kanker
Periampullaire kanker
Ondersteuning
Department of Surgery and department of Pathology
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Diagnostic accuracy of NGS
Achtergrond van het onderzoek
Determination of the added value of Targeted Next-Generation Sequencing in the diagnostic process of patients with a suspect lesion in or around the pancreas, whose morphological assessment of the preoperative cytology sample is benign or inconclusive.
Doel van het onderzoek
Targeted Next Generation Sequencing (NGS) can distinguish benign pancreatic diseases, such as pancreatitis, from pancreatic malignancies during the diagnostic proces of patients with an uncertain diagnosis and treatment plan.
Onderzoeksopzet
After patient inclusion is complete
Onderzoeksproduct en/of interventie
The cytology material, obtained during fine-needle aspiration or brush, is analyzed with NGS, the molecular findings are integrated during the diagnostic process.
Algemeen / deelnemers
Wetenschappers
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• Patient with suspect pancreatic or periampullary lesion (papil; duodenum; distal bile duct); or patients with suspect cysts
• Sufficient radiological images; assessed by specialized radiologist
• Sufficient clinical assessment; including bilirubine levels and CA19.9 levels
• Cytology sample available for pathological assessment; either obtained with FNA, brush or punction from cystic wall
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
none
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL6819 |
| NTR-old | NTR7006 |
| Ander register | Protocolnummer METC : P17.213 |
Samenvatting resultaten
https://www.ncbi.nlm.nih.gov/pubmed/28775172