Hypothesis: arterial oxygen concentrations induce dose-dependent hemodynamic and microcirculatory changes during oxygen supply in mechanically ventilated, post cardiac surgery, ICU patients. Aim: In this study we want to investigate the effects of…
ID
Bron
Verkorte titel
Aandoening
Intensive Care (IC) patients, Oxygen concentrations, Hyperoxia, CABG
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Cardiac output
Achtergrond van het onderzoek
Single-center prospective crossover trial studying the effects of short-term hyperoxia on hemodynamic parameters, cerebral perfusion and microcirculation in mechanically ventilated patients admitted to the ICU after elective coronary bypass grafting surgery
Doel van het onderzoek
Hypothesis: arterial oxygen concentrations induce dose-dependent hemodynamic and microcirculatory changes during oxygen supply in mechanically ventilated, post cardiac surgery, ICU patients.
Aim: In this study we want to investigate the effects of supplemental oxygen on:
- dynamic cardiovascular parameters
- cerebral perfusion and critical closing pressure
- microcirculation
Onderzoeksopzet
T1 Baseline: PaO2 targeted FiO2 level
T2 Intervention: FiO2 at 90% (15-30 min)
T3 Control: PaO2 targeted FiO2 level
Onderzoeksproduct en/of interventie
Primary:
Increase of supplemental oxygen (FiO2) from baseline level (according to PaO2) to 90%.
Secondary:
- Mandatory inspiratory hold maneuvers.
- Arm occlusion with the Rapid Cuff Inflator by applying pressure above the patient’s systolic blood pressure.
Algemeen / deelnemers
Wetenschappers
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Mechanically ventilated adult patients admitted to the ICU after elective coronary bypass grafting surgery
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Pregnancy
- Hemodynamic instability with a baseline mean arterial pressure (MAP) < 70 mm Hg, central venous pressure (CVP) >18 mm Hg and / or dependence on moderate to high dosages of inotropic drugs after admittance to the ICU
- Severe arrhythmias
- Intra-cardiac shunts
- Symptomatic peripheral vascular disease
- Symptomatic pulmonary disease
- Clinically significant aortic aneurysm
- Significant valvular regurgitation
- Prior diagnosis of aberrant cardiovascular anatomy
Opzet
Deelname
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| Register | ID |
|---|---|
| NTR-new | NL4960 |
| NTR-old | NTR5064 |
| Ander register | : P14.046 METC LUMC |