The difference in surgical conditions between deep or moderate neuromuscular block is absent during sevoflurane anesthesia
ID
Bron
Verkorte titel
Aandoening
not applicable, mostly healthy individuals
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Leiden Surgical rating score
Achtergrond van het onderzoek
To assess whether a deep neuromuscular block provides better surgical conditions (L-SRS) than a moderately deep block as derived from a surgical rating score during sevoflurane anesthesia.
Doel van het onderzoek
The difference in surgical conditions between deep or moderate neuromuscular block is absent during sevoflurane anesthesia
Onderzoeksopzet
N.A.
Onderzoeksproduct en/of interventie
deep neuromusculair block vs moderate neuromusculair block
Algemeen / deelnemers
Wetenschappers
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
(i) Patients that will undergo an elective laparoscopic (donor) nephrectomy;
(ii) ASA class I-III
(iii) > 18 years of age;
(iv) Ability to give oral and written informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
(i) Known or suspected neuromuscular disorders impairing neuromuscular function;
(ii) Allergies to muscle relaxants, anesthetics or narcotics;
(iii) A (family) history of malignant hyperthermia;
(iv) Women who are or may be pregnant or are currently breast feeding;
(v) Renal insufficiency, as defined by serum creatinine x 2 of normal, or urine output < 0.5 ml/kg/h for at least 6 h. When available, other indices will be taken into account as well such as glomerular filtration rate < 60 ml/h and proteinuria (a ratio of 30 mg albumin to 1 g of creatinine).
(vi) Previous retroperitoneal surgery at the site of the current surgery.
(vii) Body mass index > 35 kg/m2
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL7844 |
| Ander register | METC LUMC : P17.049 |