Presence of Group A streptococci in children's throat is associated with worsening or onset of tics
ID
Bron
Verkorte titel
Aandoening
Tourette syndrome
Tics
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The main study outcome is onset of tics (ONSET study) and tic exacerbation (COURSE study), as assessed by the Yale Global tic severity scale (YGTSS) plus Premonitory Urge for Tics Scale (PUTS).
Doel van het onderzoek
Presence of Group A streptococci in children's throat is associated with worsening or onset of tics
Onderzoeksopzet
Assessments every four years during 16 months (COURSE) and 3 years (ONSET)
Onderzoeksproduct en/of interventie
None
Algemeen / deelnemers
Hanzeplein 1
P.J. Hoekstra
Groningen 9713 GZ
The Netherlands
p.j.hoekstra@med.umcg.nl
Wetenschappers
Hanzeplein 1
P.J. Hoekstra
Groningen 9713 GZ
The Netherlands
p.j.hoekstra@med.umcg.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
ONSET:
• First degree relative of person with TS or another chronic tic disorder according to DSM IV-TR criteria (American Psychiatric Association). This may include children with a half-sister/-brother with a tic disorder.
• Aged 3-10 years, male or female
Parents and patients have provided written informed consent and assent as appropriate according to ethical regulation
COURSE:
• TS or another chronic tic disorder according to DSM IV-TR criteria (American Psychiatric Association)
• Age 3 through 16 years, male or female
• Parents and patients have provided written informed consent and assent
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
ONSET:
• Presence of tics. This will be checked by using the tic check list of the YGTSS.
• Current or previous presence of OCD
• Current or previous presence of trichotillomania
• Serious medical illness
• Child treated with antibiotics in the past 1 month.
• Children and/or parents are unable to understand and comply with protocol.
COURSE:
• Serious medical illness
• Child treated with antibiotics in the past 1 month
• Children and/or parents are unable to understand and comply with protocol
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4662 |
| NTR-old | NTR4814 |
| Ander register | European Commission : 278367 |