Multiple studies have shown that dietary restriction extends lifespan in different animal species ranging from worms to rats. The beneficial effect of calorie restriction on life span may function in part through its ability to increase stress…
ID
Bron
Verkorte titel
Aandoening
Dietary restriction, Preoperative nutrition, Acute phase response, Surgery
Preoperative voeding, Dieet, Acute fase reactie, operatie
Ondersteuning
Erasmus MC
Dr. Molewaterplein 50
3015 Ge Rotterdam
010-7043683
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Postoperative course of CRP, IL-6, IL-8 and IL-10.<br>
This is an pilot study and therefore no samplesize calculation is performed.
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
Multiple studies have shown that dietary restriction extends lifespan in different animal species ranging from worms to rats. The beneficial effect of calorie restriction on life span may function in part through its ability to increase stress resistance.We hypothesize that the mechanisms involved in extended longevity may also be tapped for short-term clinical benefits against acute stress such as the acute phase response after surgery.
Onderzoeksopzet
Preoperatively and at days 1,2,3 and 4 the donors blood samples will be collected and analyzed.
Preoperatively and at 1,3,6 and 12 months postoperatively donors are asked to complete forms related to the quality of life and the ability to perform daily tasks and (if applicable) the time of regaining working activities.
Onderzoeksproduct en/of interventie
Based on reported calorie intake patients randomized to the dietary restriction group start a 30% calorie restricted diet three days pre-operatively. The day before surgery the donor is allowed to have a light breakfast followed by 12 hours of fasting. Until midnight preoperatively they are allowed to drink water ad libitum.
Algemeen / deelnemers
PO Box 2040
J.N.M. IJzermans
Rotterdam 3000 CA
The Netherlands
+31 (0)10 7033727
j.ijzermans@erasmusmc.nl
Wetenschappers
PO Box 2040
J.N.M. IJzermans
Rotterdam 3000 CA
The Netherlands
+31 (0)10 7033727
j.ijzermans@erasmusmc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Scheduled for laparoscopic donor nephrectomy;
2. 18 years ¡Ü age ¡Ü 80 years;
3. BMI ¡Ý 18.5.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
If inclusion criteria are not met.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1765 |
| NTR-old | NTR1875 |
| Ander register | METC Erasmus MC : METC-2007-1999 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |