Breath hold techniques may pose an advantage over free breathing techniques for irradiation of pancreatic cancer
ID
Bron
Verkorte titel
Aandoening
Resectable pancreatic cancer, borderline resectable pancreatic cancer, irresectable pancreatic cancer, radiochemotherapy, breath hold technique for radiation, fiducial markers
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Comparison of preparatory, inter and intra fraction tumour motion between free breathing and breath hold conditions
Achtergrond van het onderzoek
Pilot study of 10 patients with pancreatic cancer eligible for radiochemotherapy for (borderline) resectable or irresectable pancreatic cancer to investigate whether irradiation with a breath hold technique is feasible, and leads to less inter fraction position variation and intra fraction motion, than free breathing methods.
Doel van het onderzoek
Breath hold techniques may pose an advantage over free breathing techniques for irradiation of pancreatic cancer
Onderzoeksopzet
- Acquirement of data before and during treatment of patients giving informed consent
- Analysis of all data untill 3 months after closure of accrual
- Interpretation of data and making manuscript within 6 months after closure of accrual.
Onderzoeksproduct en/of interventie
No additional therapeutic interventions
During preparatory CT and once weekly during fractionated radiation, additional imaging shall be performed in breath hold conditions.
Algemeen / deelnemers
Department of radiation oncology<br>
Meibergdreef 9
G. Tienhoven, van
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5665591
g.vantienhoven@amc.uva.nl
Wetenschappers
Department of radiation oncology<br>
Meibergdreef 9
G. Tienhoven, van
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5665591
g.vantienhoven@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Patients with pancreatic cancer, locally advanced or (borderline) resectable status, who are treated with radio(chemo)therapy;
- WHO performance status of 0-2;
- Written informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Inability to undergo the additional treatment planning CT scan and fluoroscopy;
- Serious lung condition precluding breath-hold
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4158 |
| NTR-old | NTR4317 |
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