It is expected that the incidence of eleven Chlamydia species in deep respiratory secretions from patients with community acquired pneumonia will be 5%, in accordance with previous research.
ID
Bron
Verkorte titel
Aandoening
Repiratory infections
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Incidence of eleven Chlamydia species in deep respiratory secretions from patients with pneumonia.
Achtergrond van het onderzoek
Rationale: The current world population is 7.8 billion as of January 2020 and is ever increasing. Due to this growing population, together with global warming, the risk of severe epidemics is rising. Most new epidemics are associated with an animal origin. As such, awareness of zoonotic diseases is highly important. Among the zoonotic respiratory infections, Chlamydiae are increasingly identified. Wherease C. psittaci and C. pneumoniae were already known, lately also C. gallinacea, C. avium and C. cavia have been involved in respiratory infections occasionally. Unfortunately, since the pathogens are not routinely tested, the incidence of these infections remains unclear.
Objective: in this study we aim to investigate incidence of eleven Chlamydia species in deep respiratory secretionss from patients with community acquired pneumonia. The additional value of faecal samples will be investigated. In addition, we aim to characterize clinical patient factors and outcomes in these Chlamydia infections.
Study design: Prospective cohort design. Adult patients are included when they present with community-acquired pneumonia (CAP) at the Emergency Department or Outpatient department and are admitted to the hospital.
Study population: adult patients with CAP
Main study parameters/endpoints: Primary: incidence of eleven Chlamydia species in deep respiratory secretionss. Secondary: incidence of eleven Chlamydia species faecal samples. Tertiary: level of agreement between between deep respiratory secretions and faecal samples. comparison between animal contact between patients with our without chlamydial infection. Comparison between patient characteristics of patients with or without chlamydial infection. Comparison between clinical outcomes of patients with or without chlamydial infection.
Nature and extent of the burden and risks associated with participation, benefit and group relatedness: in addition to routine clinical data, the patients will be questioned about animal contacts and they will be asked for collection of faecal samples.
Doel van het onderzoek
It is expected that the incidence of eleven Chlamydia species in deep respiratory secretions from patients with community acquired pneumonia will be 5%, in accordance with previous research.
Onderzoeksopzet
T0 = hospital admission, T1= 30 days after hospital discharge
Algemeen / deelnemers
Wetenschappers
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Adult
- Pneumonia defined by a new pulmonary infiltrate on chest radiograph described by the attending physician, in combination with at least two of the following criteria: cough, sputum production, temperature > 38.0 °C or < 35.0°C, auscultatory findings consistent with pneumonia, C-reactive protein concentration > 15 mg/l, and white blood cell count > 10 x 109 cells/l or < 4 x 109 cells/l or > 10% of rods in leukocyte differentiation.
- Active sputum production
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Not giving informed consent
- Not able to give the informed consent (e.g., suffering from dementia, delirium, mentally disabled) except for patients suffering from acute loss of consciousness due to pneumonia (informed consent will be asked from the spokesperson)
Opzet
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| Register | ID |
|---|---|
| NTR-new | NL9529 |
| Ander register | METC Z : METCZ20200148 |