We expect that MS could be detected by an electronic nose by analysing exhaled volatile compound patterns.
ID
Bron
Verkorte titel
Aandoening
Multiple Sclerosis
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Investigate the accuracy of the AeonoseTM in distinguishing breath prints of patients with various types and stages of MS and sujects without MS, whether it can assist in diagnosing MS, and whether it can monitor its progression.
Achtergrond van het onderzoek
There is not yet a quick test nor a non-invasive method to identify patients with Multiple Sclerosis (MS) or distinguish between various types of MS. An electronic nose is a diagnostic device to detect patterns in the compounds that are exhaled by patients. The disease-specific pathways give rise to specific patterns that aid in detecting diseases. Exhaled breath data and clinical parameters will be used to develop a predictive model, based on supervised machine learning techniques. We will investigate whether an eNose can detect MS and monitor the disease progression.
Doel van het onderzoek
We expect that MS could be detected by an electronic nose by analysing exhaled volatile compound patterns.
Onderzoeksopzet
One measurement
Onderzoeksproduct en/of interventie
Participants will breathe trough the AeonoseTM for 5 minutes.
Algemeen / deelnemers
Wetenschappers
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Inclusion criteria for patients with MS:
- Diagnosis MS confirmed by a neurologist
- Age >18 years
Inclusion criteria control subjects
- Not suspicious of having MS
- Age >18 years
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Physically or cognitively being unable to use the Aeonose
- Diagnosed with another neurodegenerative or neuroinflammatory disease (besides MS)
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL9689 |
| Ander register | METC Isala : METC201013 |