Pathological neural oscillations identified with MEG source imaging will be normalized when tonic and/or burst SCS causes pain reduction
ID
Bron
Verkorte titel
Aandoening
neuropathic pain
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Differences in the power in frequency bands in cortical pain processing areas as well as attention areas during resting-state MEG, under various stimulation settings and compared with control subjects.
Achtergrond van het onderzoek
Spinal Cord Stimulation (SCS) is an invasive last-resort pain treatment and consists of electrical stimulation of the spinal cord dorsal column using an implanted electrode and pulse generator. Despite its efficacy, SCS has limited or no effect in approximately 35% of patients. Attempts to reliably predict treatment success have failed, probably due to our limited understanding of its mechanisms of action. In this explorative prospective controlled study in patients who already have a spinal cord stimulator and matched control subjects with and without chronic pain, we image with magneto-encephalography (MEG) the supraspinal effects of several SCS settings
Doel van het onderzoek
Pathological neural oscillations identified with MEG source imaging will be normalized when tonic and/or burst SCS causes pain reduction
Onderzoeksopzet
Patients with SCS will have MEG sessions with three different stimualtion settings, eacht with one week in between. Control subjects will have one MEG session.
Algemeen / deelnemers
Wetenschappers
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• Over 18 years,
• SCS for at least 3 months,
• Stable response to stimulation,
• Pulse generator suitable for burst stimulation,
• Active tip of the implanted electrode at spinal level Th8 or below,
• Pulse generator implanted in the lower body,
• Capable of participation: travelling to the institute and filling in the questionnaires
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• Severe pain that is interfering with the pain that the SCS is used for,
• Hospitalised or another form of serious decline of general health
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL8345 |
| CCMO | NL63267.091.17 |
| OMON | NL-OMON46671 |