Electrical stimulation of the sympathetic pathways by cervical spinal cord stimulation increases cerebral blood flow.
ID
Bron
Aandoening
SCS, cerebral blood flow, autoregulation
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Cerebral blood flow velocities as measured with TCD combined with cerebral oxygenation determined by NIRS.
Achtergrond van het onderzoek
Spinal Cord Stimulation has been used for many pathological conditions and has proven to improve coronary, cerebral and peripheral blood circulation. We would like to investigate the effect of spinal cord stimulation on the cerebral blood flow (CBF). We postulate that this effect is caused by the sympathetic pathway. Due to the electrical stimulation we suspect to suppress the sympathetic pathway, which in turn should cause the change in CBF.
Doel van het onderzoek
Electrical stimulation of the sympathetic pathways by cervical spinal cord stimulation increases cerebral blood flow.
Onderzoeksopzet
May-June: METC UMCG approval;
July: Start experimental measurements;
August-sep: Data-analyses.
Onderzoeksproduct en/of interventie
The frequency and amplitude of the SCS device will be changed. The pulse-width will not be changed. The frequency will be of 130 Hz, pulse-width between 100 Hz- 130 Hz. The voltage of the stimulation will be 90% of maximum voltage that is tolerated or evoking a motor response. During the experiment the SCS will be switched on and off, with an alternating timespan of 5 mins.
The whole set-up consists for each subject of 1 measurement with a maximum duration of 2 hours. The subjects will be measured only once and do not have to come back.
Algemeen / deelnemers
L.P. Govindarajan
Groningen 9712 HC
The Netherlands
+31 (0)6 12218784
lpgovindarajan@gmail.com
Wetenschappers
L.P. Govindarajan
Groningen 9712 HC
The Netherlands
+31 (0)6 12218784
lpgovindarajan@gmail.com
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Patients with SCS, stimulating the cervical myelum;
2. Age > 18 years;
3. Informed consent signed by patient.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. The presence of any other implanted electronic device (including pacemakers);
2. Pre-existing disease that can obscure follow-up or experimental set- up such as amputations;
3. Insufficient temporal bony windows;
4. The use of sympathicomimetic or sympathicolytic agents.
Opzet
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL3296 |
| NTR-old | NTR3442 |
| Ander register | : |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
Samenvatting resultaten
2.The effect of cervical transcutaneous electrical neurostimulation
on cerebral blood flow velocities, cerebral vasospasm and ischemic deficit in
secondary cerebral vasospasm after subarachnoid haemorrhage.