Eosinophils play an important role in the inflammatory processes in the lung of asthmatic patients. Mepolizumab inhibits homing of these cells. The hypothesis is tested that mepolizumab affects the kinetics of these cells in blood and sputum.
ID
Bron
Verkorte titel
Aandoening
Eosinophilic asthma, action of mepolizumab on lung inflammation.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
change in kinetics of eosinophils in the sputum
Doel van het onderzoek
Eosinophils play an important role in the inflammatory processes in the lung of asthmatic patients. Mepolizumab inhibits homing of these cells. The hypothesis is tested that mepolizumab affects the kinetics of these cells in blood and sputum.
Onderzoeksopzet
three time points for sputum induction/analysis
10 time points for blood sampling/analysis
Onderzoeksproduct en/of interventie
Mepolizumab
Algemeen / deelnemers
PO Box 85500
L. Koenderman
Utrecht 3508 GA
The Netherlands
+31 (0)88 7557552
Wetenschappers
PO Box 85500
L. Koenderman
Utrecht 3508 GA
The Netherlands
+31 (0)88 7557552
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Age>18 and younger than 70 years
Diagnosis of eosinophil asthma despite use of corticosteroids
suitable for sputum induction
>2.5 % sputum eosinophils
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Any infection (e.g. HIV, hepatitis, STD's)
Insulin dependent diabetes
Smoking at present or in the last 12 months and/or a past
history of more than 10 pack years
Proven allergic bronchopulmonary aspergillosis
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5988 |
| NTR-old | NTR6354 |
| Ander register | : 2016-001636-35 |