Long term androgen treatment in female-to-male transsexuals (FtMs) leads to changes in the ovaries: polycystic ovaries, determined by transvaginal ultrasound and histopathology. So the aim of this study is to determine wether long-term high doses…
ID
Bron
Aandoening
Androgens, ovaries, female-to-male transsexuals
Ondersteuning
Department of Obstetrics and Gynaecology in collaboration with the department of Gender Dysphoria of the VU University Medical Center.
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Ovarian morphology, in terms of:<br>
- transvaginal ultrasound<br>
- histopathological features
Achtergrond van het onderzoek
Prospective observational cohort study.
The aim of this study is to examine the ovarian effects of long-term androgen treatment in gender dysphoric females. This will enable us to provide: 1. adequate care for FtMs concerning their inner genitalia, especially ovaries and 2. provide more insight in the pathophysiologic mechanism of PCOS. Standard androgenic treatment or surgery as part of their sex-reassigment hormonal therapy will not be influenced. Morphologic changes of ovaries will be determined by transvaginal ultrasound and histopathology.
Doel van het onderzoek
Long term androgen treatment in female-to-male transsexuals (FtMs) leads to changes in the ovaries: polycystic ovaries, determined by transvaginal ultrasound and histopathology.
So the aim of this study is to determine wether long-term high doses of exogenous androgens affect ovarian morphology. In terms of: 1. transvaginal ultrasound and 2. histopathological features.
Onderzoeksopzet
T = 0: start androgenic treatment
T = 1: operation day (minimum of 12 months after start treatment)
Onderzoeksproduct en/of interventie
Standard androgenic treatment as part of their sex-reassignment hormonal therapy.
Algemeen / deelnemers
Afdeling Voortplantingsgeneeskunde (Gynaecologie en Obstetrie) <br>
VU Medisch Centrum <br>
Gebouw Zuid, F 16 <br>
Postbus 7057 <br>
1007 MB Amsterdam
M.R. Caanen
Amsterdam
The Netherlands
m.caanen@vumc.nl
Wetenschappers
Afdeling Voortplantingsgeneeskunde (Gynaecologie en Obstetrie) <br>
VU Medisch Centrum <br>
Gebouw Zuid, F 16 <br>
Postbus 7057 <br>
1007 MB Amsterdam
M.R. Caanen
Amsterdam
The Netherlands
m.caanen@vumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Diagnosis Gender Dysphoria
- >1 year cross-sex hormonal treatment
- Age 18+
- Intention to undergo sex-reassignment surgery
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Disorder of sexual development
- Concomitant pathology with known or possible endocrine effects
- Excessive alcohol or drug abuses
- Patients who explicitly declare that they do not want to participate in the study
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4632 |
| NTR-old | NTR4784 |
| Ander register | METC VUmc : 2014.402 |