1. Cannabis use increases striatal dopamine release 2. Striatal dopamine release predicts cannabis induced-psychotic experiences 3. Cannabis-induced striatal dopamine response varies as a function of genetic risk for psychosis
ID
Bron
Verkorte titel
Aandoening
cannabis
psychosis
dopamine
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
A. Striatal dopamine response after THC and placebo, as measured with PET and [18F]fallypride <br>
B. Psychotic experiences after THC and placebo, as measured with i) novel computer-assisted tasks and ii)clinical interviews
Achtergrond van het onderzoek
The study aims at elucidating the biological mechanism behind the cannabis-psychosis relationship. By using PET and [18F]fallypride, the striatal dopamine response is measured after THC or placebo exposure. Novel computer-assisted tasks as well as clinical interviewing are used to assess psychotic experiences behaviorally.
Doel van het onderzoek
1. Cannabis use increases striatal dopamine release
2. Striatal dopamine release predicts cannabis induced-psychotic experiences
3. Cannabis-induced striatal dopamine response varies as a function of genetic risk for psychosis
Onderzoeksopzet
One timepoint (t1)
Onderzoeksproduct en/of interventie
Exposure to delta-9-tetrahydrocannabinol (THC, psychoactive component of cannabis, 8 mg) and placebo
Algemeen / deelnemers
Dept. Psychiatry and Neuropsychology
PO Box 616 (loc. Vijverdal)
Rebecca Kuepper
Maastricht 6200 MD
The Netherlands
+31 (0)43 3688658
r.kuepper@sp.unimaas.nl
Wetenschappers
Dept. Psychiatry and Neuropsychology
PO Box 616 (loc. Vijverdal)
Rebecca Kuepper
Maastricht 6200 MD
The Netherlands
+31 (0)43 3688658
r.kuepper@sp.unimaas.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Aged between 18 and 50
2. Life-time use of cannabis without having experienced negative effects (e.g. bad trip, toxic psychosis)
3. BMI between 18.5 and 27
4. Having signed informed consent
5. Clinical diagnosis of non-affective schizophrenia or psychotic disorder according to DSM-IV
(REFERS ONLY TO PATIENTS)
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Head trauma
2. Respiratory, cardiovascular, neurological disease, severe renal or liver dysfunction
3. Alcohol use in excess of 5 units per day
4. Weekly use of illicit drugs (other than cannabis)
5. Current use of antipsychotic medication or medication known to interfere with the CB1 receptor (e.g. rimonabant)
6. Pregnancy and breastfeeding
7. Personal or family history of psychosis
(REFERS ONLY TO HEALTHY CONTROLS)
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1272 |
| NTR-old | NTR1318 |
| Ander register | : 200801 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |