Treatment of patients with respiratory complaints in the emergency department (ED) based on venous blood gas (VBG) results does not differ from treatment based on arterial blood gas (ABG) results.
ID
Bron
Verkorte titel
Aandoening
Respiratory complaints
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The main study endpoint is the frequency of alterations in treatment of patients with respiratory complaints in the emergency department (ED) based on venous blood gas (VBG) results compared to treatment based on arterial blood gas (ABG) results. We will assess which alterations in treatment occur, the characteristics of alterations and which ABG resuls cause the change.
Achtergrond van het onderzoek
An integral part of assessment of patients with respiratory complaints in the emergency department (ED) is determining the acid-base, ventilation and oxygenation status. Traditionally, arterial blood gas (ABG) results have been used. Previous research shows venous blood gas (VBG) results could be a reliable alternative. ABG sampling is often painful, can be challenging to perform, and carries greater risks. The primary objective of this study is to test the hypothesis that treatment of patients with resipratory complaints in the emergency department (ED) based on venous blood gas (VBG) results does not differ from treament based on arterial blood gas (ABG) results. We will assess the frequency of alterations in treatment bases on VBG results compared to treatment based on ABG results. Which alteration intreatment occur, the charesteristics of the alterations and the ABG results causing the change (pH, bicarbonate, pCO2, lactate or pO2) will be assessed.
Doel van het onderzoek
Treatment of patients with respiratory complaints in the emergency department (ED) based on venous blood gas (VBG) results does not differ from treatment based on arterial blood gas (ABG) results.
Onderzoeksopzet
Total expected study duration is 6 weeks.
Onderzoeksproduct en/of interventie
One extra blood sample will be obtained with the standard venepuncture or from the peripheral venous catheter to collect the venous blood gas. No extra vascular puncture is required.
Algemeen / deelnemers
Wetenschappers
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Patients (≥ 18 years) presenting in the ED with dyspoea, respiratory rate > 20/min or peripheral oxygen saturation <95%, a reliable saturation measured by pulse oximetry and an indication, determined by the treating physician, to determine the acid-bae, ventilation and oxygenation status by arterial blood gas.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
A potential subject who meets any of the following criteria will be excluded from participation in this study:
- Not capable to give informed consent within reasonable time after stabilisation and abating of the accompanying psychological stress, and no representative availabe to give informed consent on behalf of the patient.
- Arterial blood gas results are required for other reasons than determining the acid-base, ventilation and oxygenation status, such as determing the alveolar to arterial oxygen gradiënt (A-a gradient).
- No physician or qualified nurse available for ABG sampling.
- Failed ABG or VBG sampling after two attempts.
- Previous participation in the study.
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL8085 |
| Ander register | METC Zuyd : METCZ20190084 |