The aim of the present study is to investigate the effects of probiotic supplementation with Ecologic®Barrier on emotion processing and executive functioning in human subjects by using fMRI.
ID
Bron
Verkorte titel
Aandoening
Emotion processing and executive functioning in a healthy population.
Probiotics, Nervous System, Stress and Emotions
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Neurocognitive measures of emotion and executive functioning.
Achtergrond van het onderzoek
Changes in microbiota-gut- brain axis have been linked to alterations in emotional-cognitive behavior
consistent with some anxiety and depressive symptoms. Recently, a growing body of animal studies
proves evidences for effects of probiotics on gut microblome composition and functions. Accordingly,
the present fMRI study aims to define the effects of probiotics supplementation on emotion, executive
functioning and brain activity in a double-blind, placebo controlled design. Short term effects will be
investigated after four weeks of supplementation with probiotics from the baseline in a Healthy human
population.
Doel van het onderzoek
The aim of the present study is to investigate the effects of probiotic supplementation with Ecologic®Barrier on emotion processing and executive functioning in human subjects by using fMRI.
Onderzoeksopzet
First scanning session before starting probiotic supplementation (T0) and second scanning session within a week after the end of the intervention (T1).
Onderzoeksproduct en/of interventie
28 days of 2g multi-species probiotic (Ecologic-®Barrier)/Placebo supplementation (1x daily)
Algemeen / deelnemers
Wetenschappers
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Inclusion criteria:
- Females taking hormonal contraceptives;
- Age: 18-40 years old;
- Dutch as a mother tongue or fluent in Dutch;
- Right-handed;
- BMI range between 18–25;
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Exclusion criteria:
- Previous or current neurological, psychiatric, gastrointestinal or endocrine disorders, or other relevant medical history;
- Current or recent (<3 months) regular medication use;
- Previous or current substance/alcohol dependence or abuse within the last 3 months;
- Regular tobacco use (>5 cigarettes/day);
- Moderate alcohol use (>10 glasses a week);
- Antibiotic use 3 months prior to the study;
- Regular use of pre‐ and probiotics (and within 3 months prior to the study);
- Lactose Intolerance;
- Vegan Diet;
- Diet changed drastically over the last 3 months, or planning/willing to change diet drastically in the near future;
- MRI incompatibility (unremovable metal objects in body [plates, screws, serrefines, dental plates (pontics), metal splinters, piercings or medical plasters], active implant [e.g. pacemaker, neuro stimulator, insulin pump and/or hearing aid], head operation, epilepsy, claustrophobia).
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5693 |
| NTR-old | NTR5845 |
| CCMO | NL55406.091.15 |
| OMON | NL-OMON43866 |