We hypothesize that improving both the quantity and quality of the mitochondria by exercise training may counteract the statin-induced myocellular changes, and optimize muscle function and overall exercise capacity.
ID
Bron
Verkorte titel
Aandoening
Adopting or maintaining a physically active lifestyle is often not feasible for statin users, as muscle toxicity is the most frequent adverse effect of statins. In multiple studies it is suggested that muscle mitochondria are affected in statin users with muscle complaints. However, it is currently unknown if the exercise intolerance of statin users with muscle complaints is causally related to disturbances in muscle mitochondrial function.
Key words: statins, physically active lifestyle, exercise intolerance, muscle toxicity, mitochondrial function.
Kernwoorden: statines, fysiek actieve leefstijl, inspanningsintolerantie, spierklachten, mitochondriale functie.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
- Exercise-induced change in aerobic fitness<br>
- Exercise-induced change in mitochondrial mass and function and substrate use
Doel van het onderzoek
We hypothesize that improving both the quantity and quality of the mitochondria by exercise training may counteract the statin-induced myocellular changes, and optimize muscle function and overall exercise capacity.
Onderzoeksopzet
All measurements are performed before exercise training and after 12 weeks of exercise training.
Onderzoeksproduct en/of interventie
Combined endurance and resistance training program
Algemeen / deelnemers
Eline Allard
Nijmegen
The Netherlands
024-3614906
eline.allard@radboudumc.nl
Wetenschappers
Eline Allard
Nijmegen
The Netherlands
024-3614906
eline.allard@radboudumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
3 study groups:
1. Statin users with self-reported muscle symptoms
2. Statin users without muscle symptoms or other side effects
3. A control group, not using any statins
Inclusion criteria
- Males and females aged 40 to 70 years.
- Mentally able to give informed consent.
- Current statin user (group 1-2) for at least 3 months
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Familial hypercholesterolemia
- History of cardiovascular event within 1 year of study participation
- Known hereditary muscle defect
- Known mitochondrial disease
- Diabetes Mellitus
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5972 |
| NTR-old | NTR6346 |
| Ander register | NL59192.091.16 : 2016-2867 |