CAMEL.

In a group of young children with early manifestation of allergic disease, namely cow’s milk allergy, the course of cow’s milk allergy, as well as other allergic manifestations, and the development of the immune system will be followed prospectively.
Children under the age of 6 months with cow's milk allergy will be included in this intervention study. Intervention will be performed using probiotics, double blind centrally randomised, in 50 % of the participants during a period of 12 months, which will be administered to a standard hydrolysed formula for all participants.

Probiotic supplementation in young infants (1st 2 years of life) has a therapeutic effect, associated with upregulation of tolerance for cow's milk allergens, as well as combined with local and systemic immunomodulation and improvement of allergic manifestations in the gut, skin and airways.

In children with cow's milk allergy diagnosed by an elimination-challenge test (open), the longitudinal development will be followed from inclusion (< age 6 months) during 18 months.

All participants will recieve a hydrolysed formula (caseïne hydrolysate, Allergycare®, Friesland Foods).
2 probiotic strains (one lactobacillus and one bifidobacteria) will be added to the Allergycare® in 50% of the participants, as intervention for 12 months, randomised, double-blind.