SARS-CoV-2 Observational Study

Rationale: When a new infection emerges, most detailed information about presentation, management and clinical course is obtained from severe and/or hospitalized cases. This is currently also the case for the COVID-19 pandemic. As a consequence, little information is available from patients with mild and/or undiagnosed SARS-CoV-2 infection. These patients often contact primary care providers, either at the practice or by telephone. There is still much uncertainty about who will develop mild or more severe symptoms upon acquiring the infection and who is at risk of severe complications. We will therefore perform a study in primary care with patients presenting with acute respiratory tract infection in 4-8 European countries.

Objective: To generate information on the presentation and management of patients with community-acquired acute respiratory tract infection in primary care during the COVID-19 pandemic, to determine the proportion of these patients infected with SARS-CoV-2, and risk factors for getting COVID-19 and for a complicated course of COVID-19 disease.

Study design: Observational study with patient follow-up.

Study population: Patients aged one year and older, presenting in primary care (either in person, or phone/video), with symptoms of community-acquired acute respiratory tract infection (CA-ARTI) during the COVID-19 pandemic.

Main study parameters/endpoints: The proportion of patients with SARS-CoV-2 infection in patients presenting with CA-ARTI in primary care settings in various European countries, with description of their course of disease (illness days, non-productive days, complications and death).

determination course of disease of COVID-19 in the primary care setting

follow-up at day 7 and 28

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