Pregnancy rate after insemination would be 50% higher after application of misoprostol.
ID
Bron
Verkorte titel
Aandoening
Intra-uterine insemination, misoprostol, pregnancy, prostaglandin, vaginal suppository.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Primary outcome is clinical pregnancy defined as the presence of a fetal sac with positive cardial activity.
Achtergrond van het onderzoek
Because seminal prostaglandins play a role in the natural fertilization process, it can be hypothesized that the vaginal supplementation of exogenous prostaglandins at the time of intra-uterine insemination might enhance the chances of conception. We therefore investigate the effect of misoprostol, a prostaglandin analogue, on the success rate of intra-uterine insemination.
Doel van het onderzoek
Pregnancy rate after insemination would be 50% higher after application of misoprostol.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
Before removing the speculum after IUI, a white study suppository is placed in het posterior vaginal fornix. Each suppository contains either placebo or 400 µg of misoprostol.
Algemeen / deelnemers
De Pintelaan 185
M. Dhont
Gent 9000
Belgium
+32 92403796
Marc.Dhont@Ugent.be
Wetenschappers
De Pintelaan 185
M. Dhont
Gent 9000
Belgium
+32 92403796
Marc.Dhont@Ugent.be
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. All women presenting for intra-uterine insemination;
2. Between the age of 20 and 36 years;
3. Bilateral tubal patency was proven;
4. Total motile fraction of the semen sample was more than 1 million after preparation;
5. Informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. History of previously failed intra-uterine insemination;
2. Severe comorbidity (endometriosis, fibroma);
3. Previous allergic reactions to misoprostol.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL936 |
| NTR-old | NTR961 |
| Ander register | : |
| ISRCTN | ISRCTN76424181 |