The purpose of this pilot study is to describe the changes in NK cell percentages and therefore is hypothesis generating rather than hypothesis testing
ID
Bron
Verkorte titel
Aandoening
Not applicable
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Percentage of NK cells with activating and inhibitory receptors in peripheral blood
Achtergrond van het onderzoek
The human the menstrual cycle is a complex physiological process with profound effects on many organs and systems in the body including the immune system. Part of the innate immune system, peripheral blood NK cells show dynamic changes in number as well as cytotoxicity during the menstrual cycle, but the exact nature and consequence of these changes in not yet understood. In the present study, we characterize the variation in the natural killer cell receptors associated with different phases of the menstrual cycle in women with a natural menstrual cycle and also in men. We compare activating and inhibitory peripheral natural killer cell receptors at strictly defined follicular (day 7) and luteal (day 21) phases of the menstrual cycle. The results will advance our understanding of the timing and consequence of the natural hormonal cycle on immune environment.
Doel van het onderzoek
The purpose of this pilot study is to describe the changes in NK cell percentages and therefore is hypothesis generating rather than hypothesis testing
Onderzoeksopzet
Women and men will be asked to visit the TVDC to sample peripheral blood with a venapunction at day 1, 7 and 21 of the menstrual cycle during 2 consecutive cycles. Furthermore, women will be asked to sample menstrual blood at day 1 of the menstrual cycle during 2 consecutive cycles.
Onderzoeksproduct en/of interventie
None
Algemeen / deelnemers
Wetenschappers
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Group 1: healthy women (no chronic medical conditions like chronic hypertension, chronic kidney failure, chronic immune conditions (SLE) or chronic medication use) with a regular natural menstrual cycle of 28 days (+/- 3 days), defined by no contraceptive use or healthy women with a copper spiral
Group 2: healthy men (no chronic medical conditions, like chronic hypertension, chronic kidney failure, chronic immune conditions (SLE) or chronic medication use)
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Current or recent (<2 weeks) symptomatic infection
- Previous pregnancy with complications, such as repeated miscarriages, preeclampsia, or diabetes gravidarum
- Unable to give mentally capable consent in Dutch
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Toelichting
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL8701 |
| Ander register | METC azM/UM : METC19-054 |