The one-year graft survival of a second kidney transplant will be inferior to the one-year graft survival of a first kidney transplant.
ID
Bron
Verkorte titel
Aandoening
End stage renal disease, allograft failure
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The one-year graft survival of a second kidney transplant compared to a first
kidney transplant.
Achtergrond van het onderzoek
Kidney transplantation has become the most preferred form of treatment for kidney failure. Currently, around 1 million people in the United States are suffering from kidney failure. Annually, an approximate number of 15,000 kidney transplantations are performed in the United States. As a result of improvements in all aspects of kidney transplantation in the past few decades, the allograft survival has been increased. Unfortunately, in some cases a second transplantation is necessary. A second kidney transplantation could have a decreased allograft survival since this group has already been exposed to alloantigens and thereby has experienced loss of their first graft. Nevertheless, the success rates of second kidney transplantations after a first graft was lost (especially early after transplantation) is not completely known. We want to conduct a systematic review and meta-analysis to assess the graft survival of a second kidney transplantation compared to a first kidney transplantation in adults (> 18 years) We want to search PubMed for studies that examined the graft survival of a second kidney transplant in recipients > 18 years and complied our eligibility criteria. Our primary outcome is the one-year graft survival of a second kidney transplant compared to a first kidney transplant. Results are reported with an Odds Ratio (OR), using a random effects model from Cochrane Statistical Package Review Manager 5.3.
Doel van het onderzoek
The one-year graft survival of a second kidney transplant will be inferior to the one-year graft survival of a first kidney transplant.
Onderzoeksopzet
1 year
5 years
Onderzoeksproduct en/of interventie
Systematic literature review using EMBASE, MEDLINE ALL Ovid, the Cochrane Central Register of Trials, Web of Science Core Collection and Google scholar.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Patients of 18 years and older who recieved a second kidney transplant
2. Clinical trials, cohortstudies, retrospective studies, longitudinal studies and prospective studies.
3. English-language studies
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Case reports and conference reports.
2. Studies included preemptive kidney transplantation
3. Studies included nephrectomy
4. Studies comparing influences of immunosuppressants, HLA-matching, thrombosis, noncompliance or trauma-death donors
5. Studies that combine kidney transplantation with another organ transplantation
6. Studies who did not mention the one-year graft survival of the second kidney transplant
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Toelichting
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL8707 |
| Ander register | Erasmus MC - own investigation and funding : ErasmusMC220781 |