Different dietary proteins have a different effect on blood pressure-related mechanisms.
ID
Bron
Verkorte titel
Aandoening
Hypertension
High blood pressure
Proteins
Hoge bloeddruk
Hypertensie
Eiwitten
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Acute TPR response (derived according to the equation; MAP = CO x TPR) on each clinical investigation day during first 4 hours after consumption of supplements. Mean Arterial Pressure (MAP) and Cardiac Output (CO) will be measured.
Achtergrond van het onderzoek
AAPRES is a human intervention study with a randomized crossover design that investigates the acute effects of several dietary proteins on blood pressure-related mechanisms.
Doel van het onderzoek
Different dietary proteins have a different effect on blood pressure-related mechanisms.
Onderzoeksopzet
6 clinical investigation days with 1 week wash-out on which every hour postprandial measurements will be performed.
Onderzoeksproduct en/of interventie
First 2 weeks weight maintaining standardized diet (15 en% protein, 30 en% fat and 55 en% carbohydrates). Next 6 weeks weekly clinical investigation days on which the acute postprandial effects of different types of protein supplements and different types of carbohydrate supplements will be investigated.
Publiek
Dep. Human Biology
P.O. Box 616
J. Dopheide
Maastricht 6200 MD
The Netherlands
j.dopheide@maastrichtuniversity.nl
Wetenschappelijk
Dep. Human Biology
P.O. Box 616
J. Dopheide
Maastricht 6200 MD
The Netherlands
j.dopheide@maastrichtuniversity.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Men and women;
2. BMI 25-35 kg/m2;
3. High normal BP or untreated grade 1 hypertension (SBP 130-159 mm Hg and/or DBP 85-99 mm Hg);
4. Age between 20 - 70 years;
5. No smoking;
6. Stable weight in last 3 months (+/- 2 kg).
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Presence of urinary protein;
2. eGFR < 60 ml/min/1.73 m2;
3. Fasting glucose > 7 mmol/l;
4. Use of prescription medication that could influence BP or vascular function;
5. Gastrointestinal, cardiovascular, pulmonary, liver or renal disease;
6. Food allergies, a special diet or vegetarian;
7. Unwillingness to stop use of vitamin or dietary supplements.
Opzet
Deelname
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Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2560 |
| NTR-old | NTR2678 |
| CCMO | NL34527.068.10 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |
| OMON | NL-OMON36655 |