The maternal diet is highly responsible for the composition of breast milk which will result in at least differences between cultures and geographical separated populations. The maternal diet and breastmilk composition will show off in the…
ID
Bron
Aandoening
Breast milk composition, maternal, infant and child gastrointestinal microbiome, maternal diet
Ondersteuning
150 1 - 24T 1 Complex Building - Trunghoa -
Nhanchinh - Thanh Xuan
Hanoi - Vietnam
UMCG, Groningen, The Netherlands
Subsidy project by Transitie II en Pieken, project number T1003
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Composition of breast milk and its relationship with the maternal diet,
Microbiome of the breastfed infant
Achtergrond van het onderzoek
It is well known that breast milk composition differs from mother to mother. There is compiling evidence that the maternal diet (life long and short term) has an enormous effect on breast milk composition. This study will investigate possible differences in breast milk composition from Vietnamese women living in urban (Hanoi and HCMC) and rural (Ha Long Bay [fish-eating], Phu Tho and Tien Giang [rice-fish-eating]) regions. It is expected that within Vietnam relatively big differences will exist between breast milk compositions from mothers from the here fore mentioned regions.
Since breast milk is a strong determinant for the type of intestinal microbiome to develop in the infant during the breastfeeding period, and this developed microbiome is considered to have a relevant impact on the microbiome at older age, faeces will be collected from the breast fed infants, as well as from brothers or sisters (1-4 years of age) that have been breastfed before. Furthermore, the maternal intestinal microbiome is considered to be of importance (as aninoculant) for infant’s intestinal microbiome.
Doel van het onderzoek
The maternal diet is highly responsible for the composition of breast milk which will result in at least differences between cultures and geographical separated populations. The maternal diet and breastmilk composition will show off in the composition of of the infant's gastrointestinal microbiome, tracking into childhood
Onderzoeksopzet
Breast milk and fecal samples are taken around the 4th week of lactation.
Onderzoeksproduct en/of interventie
No intervention. . This study will investigate possible differences in breast milk composition from Vietnamese women living in urban (Hanoi and HCMC) and rural (Ha Long Bay [fish-eating], Phu Tho and Tien Giang [rice-fish-eating]) regions.
Publiek
Anne Schaafsma
Leeuwarden 8901 MA
The Netherlands
+31 (0)58 2992424
anne.schaafsma@frieslandcampina.com
Wetenschappelijk
Anne Schaafsma
Leeuwarden 8901 MA
The Netherlands
+31 (0)58 2992424
anne.schaafsma@frieslandcampina.com
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• Apparently healthy, well-nourished Vietnamese lactating women, who gave normal vaginal birth to an apparently healthy term infant (± 4 weeks old).
• No pregnancy complications
• This new-born, with normal birth proportion according to the region, is at least their second child and the new born is breastfed (at least 75% of total diary milk intake)
• Apparently healthy brother or sister in the age of 1-4 years, with no signs of diarrhea and who were breastfed during the first months of infancy
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• Medication that may influence the breast milk composition (medicines that require a special diet, or disturb appetite, or are known to affect the intestinal bacteria)
• Maternal BMI before pregnancy was not in the normal range (<23).
Opzet
Deelname
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In overige registers
Register | ID |
---|---|
NTR-new | NL4185 |
NTR-old | NTR4335 |
Ander register | FrieslandCampina : Anne Schaafsma |
ISRCTN | ISRCTN wordt niet meer aangevraagd. |