Intracranial atherosclerosis is an important cause of ischemic stroke and transient ischemic attack (TIA). Ischemic stroke or TIA in the posterior circulation accounts for approximately 20 to 30% of all ischemic events. We hypothesize that arterial…
ID
Bron
Verkorte titel
Aandoening
Atherosclerosis; ischemic stroke; TIA; MRI
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The presence or absence of intracranial vessel wall abnormalities in arteries of the intracranial posterior circulation. Presence of atherosclerosis is defined as any irregularity of the arterial vessel wall.
Doel van het onderzoek
Intracranial atherosclerosis is an important cause of ischemic stroke and transient ischemic attack (TIA). Ischemic stroke or TIA in the posterior circulation accounts for approximately 20 to 30% of all ischemic events. We hypothesize that arterial vessel wall abnormalities are also common in the posterior circulation, and are an important underlying cause of obstruction of arteries in the intracranial posterior circulation and subsequent ischemic stroke. Ultimately, for wide clinical application of intracranial vessel wall imaging, a translation has to be made to lower field strength MR scanners (3.0 tesla).
The primary objective of the current study is to compare the presence or absence of arterial vessel wall abnormalities in the intracranial posterior circulation in patients with TIA or ischemic stroke with those of healthy controls using 7.0 tesla MRI. The secondary objective is to assess the sensitivity of 3.0 tesla MRI to detect the vessel wall abnormalities visualised with 7.0 tesla MRI.
Onderzoeksopzet
All participating subjects will undergo two MRI examinations, one on the 3.0 tesla MRI scanner, and one on the 7.0 tesla MRI scanner. In patients, both MRI examinations will be performed as soon as possible, but at the latest within 3 months, after symptom onset. A minimum of 12 hours is taken in between both examinations, to make sure the contrast agent has washed out sufficiently.
For measurement of clinical outcome after ischemic stroke or TIA a follow-up survey will be conducted at 3 months and at 1, 2 and 3 year(s) after inclusion in this study.
Onderzoeksproduct en/of interventie
N/A
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
In order to be eligible to participate in this study, a subject must meet all of the following criteria:
1. ¡Ý 18 years of age.
Additional inclusion criteria for ischemic stroke / TIA patients:
1. TIA or ischemic stroke in the posterior circulation territory (= supplied via the vertebral and basilar arteries or their branches);
2. Possibility to perform MRI scanning within 3 months after onset of relevant ischemic symptoms.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
A potential subject who meets any of the following criteria will be excluded from participation in this study:
1. Allergic reaction to gadolinium or one of the constituents of its solution for administration;
2. Impossibility to undergo MRI (claustrophobia, implants or metal objects in or around the body);
3. Severely impaired renal function (severe renal insufficiency, GFR <30mL/min/1.73m2; or nephrogenic systemic fibrosis / nephrogenic fibrosing nephropathy (NSF/NFD));
4. Pregnancy.
Additional exclusion criteria for ischemic stroke / TIA patients:
1. A TIA or ischemic stroke secondary to a surgical or interventional procedure;
2. Previous vertebrobasilar surgery or endovascular therapy.
Additional exclusion criteria for healthy volunteers:
1. History of cerebral events (e.g. ischemic stroke, TIA, hemorrhage).
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5567 |
| NTR-old | NTR5688 |
| CCMO | NL43704.041.13 |
| OMON | NL-OMON47288 |