ETMI increases the detection rate of early neoplasia in BE patients with 40% or more compared to standard video endoscopy
ID
Bron
Verkorte titel
Aandoening
Barrett's esophagus
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. Number of patients with early neoplasia detected with ETMI or SVE;
2. Number of lesions with early neoplasia detected with ETMI and SVE.
Achtergrond van het onderzoek
Endoscopic Trimodal IMaging is a new imaging device that incorperates high-resolution white light endoscopy with autofluorescence imaging and narrow band imaging. Our aim of this study is to compare ETMI with standard video endoscopy for the detection of early neoplastic lesions in Barrett's esophagus with an intermediate risk profile in a non-expert setting.
Barrett's esophagus patients with confirmed low-grade dysplasia by two expert GI pathologist will undergo ETMI and standard video endoscopy by two different endoscopists from non-university hospitals with no specific expertise in the detection of early neoplastic lesions in Barrett's esophagus.
Doel van het onderzoek
ETMI increases the detection rate of early neoplasia in BE patients with 40% or more compared to standard video endoscopy
Onderzoeksproduct en/of interventie
ETMI-gastroscopy and standard video gastroscopy
Publiek
Bldg. C2-210, Meibergdreef
J.J.G.H.M. Bergman
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5669111
j.j.bergman@amc.uva.nl
Wetenschappelijk
Bldg. C2-210, Meibergdreef
J.J.G.H.M. Bergman
Amsterdam 1105 AZ
The Netherlands
+31 (0)20 5669111
j.j.bergman@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Barrett's esophagus patients with low-grade dyplasia comfirmed by two expert GI pathologists;
2. Written informed consent
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Presence of active erosive esophagitis grade A according to the Los Angles classification of erosive esophagitis;
2. Presence of conditions precluding histological sampling of the esophagus (e.g. esophageal varices, coagulation disorders, anticoagulant therapy);
3. < 18 years
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL853 |
| NTR-old | NTR867 |
| Ander register | : N/A |
| ISRCTN | ISRCTN91816824 |