ID
Bron
Verkorte titel
Onderzoeksproduct en/of interventie
Achtergrond van het onderzoek
10 healthy volunteers and 10 patients will be subjected to a Buspiron-Challange-Test during functional MRI. During the morning of the test blood samples will be collected (6 times 5 ml) to assess the concentration prolactin, ACTH, GH and cortisol. Furthermore, dyspeptic symptoms will be scored during the test.
Onderzoeksproduct en/of interventie
Single dose of Buspiron (30 mg).
Publiek
P.O. Box 22660
G.E.E. Boeckxstaens
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5667375
g.e.boeckxstaens@amc.uva.nl
Wetenschappelijk
P.O. Box 22660
G.E.E. Boeckxstaens
Meibergdreef 9
Amsterdam 1100 DD
The Netherlands
+31 (0)20 5667375
g.e.boeckxstaens@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Healthy volunteers: absence of gastrointestinal symptoms, Nepean Dyspepsia Index (NDI) score < 5, > 18 years of age.
Patients: Nepean Dyspepsia Index (NDI) score >25, > 18 years of age.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Healthy volunteers: use of drugs that affect gastrointestinal motility (antidepressants, opiates, NSAID’s, calcium-blockers, nitrates), previous abdominal surgery, epilepsy, severe liver of renal insufficience, depression, claustrophobia, metal
implants, not be able to lie down for 15 minutes.
Patients: use of drugs that affect gastrointestinal motility (antidepressants, opiates, NSAID’s, calcium-blockers, nitrates), IBS, previous abdominal surgery, epilepsy, severe liver of renal insufficience, depression, claustrophobia, metal
implants, not be able to lie down for 15 minutes.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL26 |
| NTR-old | NTR48 |
| Ander register | : N/A |
| ISRCTN | NO ISRCTN (cancelled) |