We hypothesize that administration of intravenous atropine during induction of propofol/remifentanil may have a positive effect on the hemodynamic profile and peripheral and cerebral tissue oxygenation during and after induction of anesthesia.
ID
Bron
Aandoening
hemodynamics
(cerebral) tissue oxygenation
general anesthesia
Ondersteuning
hanzeplein 1
9713 EZ groningen
050-3616161
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Hemodynamics and tissue oxygenation.
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
We hypothesize that administration of intravenous atropine during induction of propofol/remifentanil may have a positive effect on the hemodynamic profile and peripheral and cerebral tissue oxygenation during and after induction of anesthesia.
Onderzoeksopzet
Day of surgery.
Onderzoeksproduct en/of interventie
All patients will receive a standard anesthesia based on propofol and remifentanil. During the induction of anesthesia patients will randomly receive either atropine 500ug or saline. If necessary, hemodynamic support will be provided by continuous infusion of norepinephrine as in normal clinical practice to maintain adequate perfusion pressure defined as mean arterial pressure 60 mmHg. Hemodynamic parameters as well as peripheral and cerebral tissue oxygenation and microvascular blood flow will be monitored noninvasively and recorded.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Patients requiring general anaesthesia;
2. Patients age 18 years and older;
3. Patient and surgical procedure appropriate for treatment with atropine.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Patients refusal;
2. Pregnancy;
3. Patients age < 18 years;
4. Patients in which atropine is contra-indicated.
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL3470 |
| NTR-old | NTR3622 |
| Ander register | METC UMCG : 2012/218 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |