This pilot study is a feasibility study to verify a shortened scan time duration. We hypothesize that the 30-min protocol provides results as reliable as the 90-min protocol.
ID
Bron
Verkorte titel
Aandoening
Pilot study: healthy volunteers only.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
From both the 90-min dynamic data and the 30-min static data, several values will be computed. These include NET binding potentials (BP), standardized uptake values (SUV) and K values for each region of interest (LC and projection areas), which will then be used to compute ratios using appropriate reference tissue models
Achtergrond van het onderzoek
This study is a pilot study in healthy volunteers to verify PET scan time reduction, after which in the intended future study the same procedure will be used to investigate the noradrenaline system in groups of patients with Alzheimer's disease, Parkinson's disease and Down syndrome.
Doel van het onderzoek
This pilot study is a feasibility study to verify a shortened scan time duration. We hypothesize that the 30-min protocol provides results as reliable as the 90-min protocol.
Onderzoeksopzet
Each subject undergoes one PET scan.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Age ≥ 50 years and < 80 years; willingness to cooperate and sign written informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Past or present developmental disorder or psychiatric disorder; abnormal results on the MMSE (<27); (subjective) memory complaints; presence of any contra-indication for PET scanning; participation in PET study in the last 12 months; use of any medication that acts on the NA system; absence of signed informed consent form.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL7923 |
| Ander register | METC UMCG : METC2019109 |