We hypothesize time till extubation of post–CABG patients can be shortened by using an early weaning protocol with ASV.
ID
Bron
Verkorte titel
Aandoening
1. Mechanical ventilation;
2. weaning;
3. Coronary Artery Bypass Grafting (CABG).
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. Duration of ventilation.
Achtergrond van het onderzoek
Adaptive support ventilation (ASV) is a microprocessor–controlled mode of mechanical ventilation that maintains an operator preset minimum minute ventilation, independent of activity of the patient. ASV provides automatic selection of ventilatory settings and continuous – breath by breath – adaptation. In addition, it’s closed–loop control switches automatically from pressure controlled (PC) mechanical ventilation to pressure support (PS) mechanical ventilation, according to the patient status.
Previous studies have tested the efficiency, safety, and adaptability of ASV. A weaning protocol based on ASV simplifies ventilatory management; in addition, ASV shortens duration of tracheal intubation after fast–track cardiothoracic surgery. We recently studied ASV in post–coronary artery bypass surgery (CABG) patients in our setting and found a reduction of the number of ventilatory–alarms and ventilator–manipulations [ISRCTN31808827; yet unpublished data]. However, weaning with ASV was not faster as compared to standard weaning. Indeed, mean duration of intubation and mechanical ventilation (i.e., time till extubation) was 17 hours – this is very much opposite to other studies on this subject, in which mean duration of time till extubation is ~ 10 hours3;4.
Aim of the study
We hypothesize time till extubation of post–CABG patients can be shortened by using an early weaning protocol with ASV.
Doel van het onderzoek
We hypothesize time till extubation of post–CABG patients can be shortened by using an early weaning protocol with ASV.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
Patients will be weaned from the ventilator using a standard protocol and an early weaning protocol.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Planned and uneventful CABG;
2. Following receipt of verbal and written information about the trial, the patient must provide signed and dated informed consent before any trial related activity is carried out.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. History of any pulmonary disease;
2. History of any previous pulmonary surgery;
3. Valve surgery;
4. Arrival at the ICU with intra–aortic balloon pump, or inotropes at a more then usual rate (maximum dosages in ml per hour: dopamine [4], norepinephrine [4], dobutamin [4] or epinephrine [any rate]).
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1101 |
| NTR-old | NTR1136 |
| Ander register | : incomplete |
| ISRCTN | ISRCTN wordt niet meer aangevraagd |