Recent clinical data showed that remote ischemic preconditioning attenuates myocardial damage during cardiac surgery. Classic preconditioning is abolished in diabetic patients. We will investigate the molecular effects of remote ischemic…
ID
Bron
Verkorte titel
Aandoening
CABG, remote preconditioning, cardioprotection
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Differences in phosphorylation of PKC-e, p38MAKP, ERK and HSP27, before and after remote preconditioing, as compared to control.
Achtergrond van het onderzoek
The aim of this clinical study is to investigate whether remote ischemic preconditioning induces a phosphorylation of signalling pathway molecules, such as PKC-e, p38MAPK, ERK and HSP27, in human myocardium.
Doel van het onderzoek
Recent clinical data showed that remote ischemic preconditioning attenuates myocardial damage during cardiac surgery. Classic preconditioning is abolished in diabetic patients. We will investigate the molecular effects of remote ischemic preconditioning on the myocardium, in both diabetics and non-diabetics.
Onderzoeksopzet
Two myocardial biopsies will be obtained, the first after sternotomy and the second 30 minutes later, but prior to cardiopulmonary bypass.
Onderzoeksproduct en/of interventie
Remote ischemic preconditioning: By inflating a automateic inflator cuff around the upper arm, we will induce forearm ischemia for 5 minutes, followed by 5 minutes of reperfusion. This cylce will be repeated 2 times.
In the control group the cuff will be placed on the upper arm, but no inflating will be done.
Publiek
University of Amsterdam, Meibergdreef 9
Postbus 22660 H1Z-120
B. Preckel
Amsterdam 1100 DD
The Netherlands
+31 20 5662162,
b.preckel@amc.uva.nl
Wetenschappelijk
University of Amsterdam, Meibergdreef 9
Postbus 22660 H1Z-120
B. Preckel
Amsterdam 1100 DD
The Netherlands
+31 20 5662162,
b.preckel@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. CABG surgery with or without valve surgery;
2. Informed consent;
3. Age >18 years.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Emergency surgery;
2. Heart failure;
3. Serious pulmonary disease;
4. Kidney failure.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1821 |
| NTR-old | NTR1931 |
| Ander register | Medical Ethical Committee, AMC, University of Amsterdam : MEC 09/008 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |