Ageing decreases mitochondrial capacity
ID
Bron
Verkorte titel
Aandoening
Sarcopenia
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The main study parameter is mitochondrial capacity, measured as the rate of recovery of muscle oxygen consumption after exercise measured using NIRS in the vastus lateralis, gastrocnemius and tibialis anterior.
Achtergrond van het onderzoek
Ageing is associated with a decline in muscle mitochondrial function. Measuring muscle mitochondrial function is challenging and to routinely assess mitochondrial function in response to exercise and dietary interventions, practical, non-invasive and robust measurements are needed. Near-infrared spectroscopy (NIRS) is a novel technique that allows to non-invasively measure mitochondrial capacity in the human muscle. Although the technique is promising in measuring mitochondrial function during ageing, it is yet be established how age-related changes in mitochondrial function differ between different muscle types. The primary objective of this study is to measure mitochondrial capacity using NIRS in young and older healthy males in three different muscles (vastus lateralis, gastrocnemius and the tibialis anterior) to give insights on how age-related changes in mitochondrial function differ between different muscle types.
Doel van het onderzoek
Ageing decreases mitochondrial capacity
Onderzoeksopzet
-
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Young
• Male, 19-25 years
• BMI 18.5-27 kg/m2
• Normal activity levels: 1-2 hour per week engaged in a structured exercise session
Elderly
• Male, 65-71 years
• BMI 18.5-27 kg/m2
• Normal activity levels: 1-2 hour per week engaged in a structured exercise session
• Short physical performance battery score >6
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• (known symptoms of) Metabolic diseases, e.g. type I or II diabetes,
• Health concerns regarding respiratory and pulmonary diseases, e.g. COPD, (exercise induced) asthma and cardiovascular disease.
• Impaired physical performance (defined as short physical performance battery score < 6) (Only for elderly group)
• Contraindications for electrical stimulation, e.g. cardiac pacemaker
• Contraindications for muscle biopsy, e.g. usage of anticoagulants (low dose aspirin allowed)
• Regular smoker (defined as smoking >5 cigarettes per week)
• Vastus lateralis skinfold >30mm
• Haemoglobin concentrations below 8.0 mmol/L
• Usage of recreational drugs, e.g. marihuana, amphetamines and cocaine during the study (starting after first screening day)
• Recent usage (within four months) of supplements with suggestive training effects, e.g. creatine phosphate, EPO or anabolic steroids.
• Current or recent (<2 weeks) participation in other clinical trials
Opzet
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL7695 |
| CCMO | NL65872.081.18 |
| OMON | NL-OMON45934 |