Rivastigmine can reverse a memory impairment that is induced by biperiden, which will be seen both behaviorally and in the EEG.
ID
Bron
Verkorte titel
Aandoening
Long-term memory.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The primary endpoint is the behavioral score on a set of memory paradigms, namely a verbal learning task, a picture memory task, and a spatial memory task. Furthermore, the brain activity (EEG and event-related potentials) will be recorded during those tasks.
Achtergrond van het onderzoek
N/A
Doel van het onderzoek
Rivastigmine can reverse a memory impairment that is induced by biperiden, which will be seen both behaviorally and in the EEG.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
Participants will participate on 4 separate test days and will be administered either rivastigmine, biperiden, a combination, or a placebo. The order of treatment will be counterbalanced.
Publiek
Dept. of Neuropsychology and Psychopharmacology
PO Box 616
Anke Sambeth
Maastricht 6200 MD
The Netherlands
0031-(0)43-3881757
anke.sambeth@psychology.unimaas.nl
Wetenschappelijk
Dept. of Neuropsychology and Psychopharmacology
PO Box 616
Anke Sambeth
Maastricht 6200 MD
The Netherlands
0031-(0)43-3881757
anke.sambeth@psychology.unimaas.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Male or female;
2. 18 to 35 years of age;
3. healthy (i.e. absence of all exclusion criteria);
4. body mass index between 18.5 and 30;
5. willingness to sign an informed consent.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. History of cardiac, hepatic, renal, pulmonary, neurological, gastrointestinal, haematological, or psychiatric ilness;
2. excessive drinking (> 20 glasses of alcohol containing beverages a week);
3. pregnancy or lactation;
4. use of medication other than oral contraceptives;
5. use of recreational drugs from 2 weeks before the experiment until the end of the study;
6. any sensory or motor deficits which could reasonably be expected to affect test performance;
7. having a first-degree relative with a psychiatric disorder.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1070 |
| NTR-old | NTR1103 |
| Ander register | VENI : grant nr. 451-07-011 |
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