These patients are difficult to diagnose due to a multitude of non-specific symptoms and the lack of fast and specific tests. In this study we will be able to investigate patients that are admitted with acute abdominal complications and observe them…
ID
Bron
Verkorte titel
Aandoening
Acute Intestinal Ischemia
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The primary endpoint of the study is the early and accurate identification of presence and severity of acute intestinal ischemia in patients. The main study parameters are plasma biomarkers indicative for intestinal damage of patients suspected of acute intestinal ischemia.
Achtergrond van het onderzoek
Acute intestinal ischemia is a life-threatening condition with a short-term mortality that can range up to 80%. Medical diagnosis and treatment have remained troublesome, due to the clinical presentation which is mostly characterized by non-specific signs and symptoms. Early unambiguous diagnosis of acute intestinal ischemia is critical to prevent progression from reversible to irreversible intestinal injury, and henceforth decrease morbidity and improve survival. We aim to validate a panel of plasma biomarkers and investigate volatile biomarkers that allow early and accurate identification of acute intestinal ischemia in patients. In addition, we aim to identify a volatile organic compound (VOC) profile specific for acute intestinal ischemia in exhaled breath.
Doel van het onderzoek
These patients are difficult to diagnose due to a multitude of non-specific symptoms and the lack of fast and specific tests. In this study we will be able to investigate patients that are admitted with acute abdominal complications and observe them in the early stages of their condition. Accordingly, we will be able to evaluate the proposed panel of biomarkers and to identify VOC patterns in patients with acute abdominal complications. Therefore, we propose that with this study we will be able to improve the diagnostic accuracy of acute intestinal ischemia, and will provide more information that guides adequate treatment.
Onderzoeksopzet
11
Onderzoeksproduct en/of interventie
There will be no interventions in this study.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Age ≥ 18 years
All consecutive patients admitted to one of the participating medical centers emergency departments (ED) or at the intensive care unit (ICU) with clinical suspicion of acute intestinal ischemia, which is based on;
o clinical manifestation;
o physical examination by the physician;
o laboratory measurements;
o physician’s consideration to perform computed tomography (CT)-scan
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Age ≤ 18 years
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL7968 |
| Ander register | METC azM/UM : METC 19-010 |