1. Different neuropathological mechanisms in Parkinson's disease and atypical Parkinsonism concerning the risk of falling; 2. Research concerning the diagnostic accuracy and sensitivity of VEMP and SVV.
ID
Bron
Verkorte titel
Aandoening
Parkinson's disease and atypical Parkinsonism.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Comparison of the test results correlate with risk of falling, vestibular complaints or disease progression.
Achtergrond van het onderzoek
The neurovestibular system of patients with Parkinson’s disease and atypical Parkinsonisms (like PSP, MSA, vascular parkinsonism and cortico-basal syndrome) are studied clinically (clinical examination and questionnaires) and by neurophysiologic testing (VEMP, BAEP, ENG and SVV). Patients and healthy volunteers are invited to participate in this study. The primary aim of this study is to have a better understanding of the neurovestibular pathofysiological mechanisms contributing to falling in parkinson’s disease and atypical parkinsonisms and to evaluate vestibular complaints in these patients.
Doel van het onderzoek
1. Different neuropathological mechanisms in Parkinson's disease and atypical Parkinsonism concerning the risk of falling;
2. Research concerning the diagnostic accuracy and sensitivity of VEMP and SVV.
Onderzoeksopzet
1. First year: 50 inclusions;
2. Second: 100 inclusions;
3. Third: 150 inclusions.
Onderzoeksproduct en/of interventie
1. BAEP;
2. ENG;
3. VEMP;
4. SVV;
5. Questionnaire.
(Total duration: 2,5 hours, only 1 visit)
Publiek
Weg door Jonkerbos 100<br>
Postbus 9015
J. Venhovens
Nijmegen 6500 GS
The Netherlands
j.venhovens@cwz.nl
Wetenschappelijk
Weg door Jonkerbos 100<br>
Postbus 9015
J. Venhovens
Nijmegen 6500 GS
The Netherlands
j.venhovens@cwz.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Age > 18 years;
2. Parkinson's disease, atypical variants (MSA, PSP, CBS and vascular) or healthy control.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. No cognitive problems;
2. Doesn't use hypnotica, sedativa or anxiolytica;
3. No other known neuro-oto-ophthalmological problems.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
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Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL3770 |
| NTR-old | NTR3928 |
| Ander register | METC Regio Arnhem/Nijmegen : 2012/393 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |