While head and neck surgeons aim for a 1 cm healthy tissue margin during resection of OSCC, pathological examination often reveals a smaller margin. Our hypothesis is that this occurs due to shrinkage of mucosa following the resection and due to the…
ID
Bron
Verkorte titel
Aandoening
Oral Squamous Cell Carcinoma (OSCC)
NL: Mondholtecarcinomen
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
To compare mucosal shrinkage (from in vivo to histopathological examination) in each arm
Doel van het onderzoek
While head and neck surgeons aim for a 1 cm healthy tissue margin during resection of OSCC, pathological examination often reveals a smaller margin. Our hypothesis is that this occurs due to shrinkage of mucosa following the resection and due to the process of preparation for pathological examination, including formalin fixation, paraffin embedding,
Onderzoeksproduct en/of interventie
Resection using thulium laser or monopolar electric knife
Publiek
Heidelberglaan 100
A.J. Pothen
Utrecht 3584 CX
The Netherlands
a.j.pothen@umcutrecht.nl
Wetenschappelijk
Heidelberglaan 100
A.J. Pothen
Utrecht 3584 CX
The Netherlands
a.j.pothen@umcutrecht.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- >18 years old
- Confirmed OSCC stage I – IVa (Oncoline, 2004)
- ASA classification I and II
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Previously operated/irradiated OSCC or other malignancy of the oral cavity.
- Stage IVb (inoperable disease)
- Co-morbidities resulting in disability to undergo surgery under general anesthesia
- Inability to sign informed consent
- impaired mental status
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4549 |
| NTR-old | NTR4692 |
| Ander register | : METC13-340 |