Consuming most calories at breakfast compared to at dinner leads to more suppression of appetite and craving and enhances insulin sensitivity.
ID
Bron
Verkorte titel
Aandoening
obesity, type 2 diabetes
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. Insulin sensitivity (hyperinsulinemic euglycemic clamp)<br>
2. Diencephalic SERT ( [123I]FP-CIT SPECT) <br>
3. Brain 5-HT neurotransmission (pharmacological MRI (phMRI) using citalopram).
Doel van het onderzoek
Consuming most calories at breakfast compared to at dinner leads to more suppression of appetite and craving and enhances insulin sensitivity.
Onderzoeksopzet
before and after diet
Onderzoeksproduct en/of interventie
Subjects will reduce their daily caloric intake with 50% for 4 weeks. Subjects will be randomized into either a hypocaloric diet group where 15% of total kcal have to be consumed with breakfast, 35% kcal with lunch and 50% kcal with dinner or a hypocaloric diet group where 50% of kcal have to be consumed with breakfast, 35% kcal with lunch and 15% kcal with dinner.
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
men
>50 y
BMI >30
fasting glucose > 5.6 and/or insulin > 74
Stable weight three months prior to study inclusion
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Use of any medication except for those related to treatment of components of the metabolic syndrome (excluding insulin, oral glucose lowering drugs, beta-blockers)
Any actual medical condition except for treated hypothyroidism and the metabolic syndrome
History of any psychiatric disorder
Shift work
Irregular sleep pattern
Intensive sports (>3/week)
Restrained eaters
History of eating disorders (anorexia, binge eating, bulimia)
Smoking, XTC, amphetamine or cocaine abuse
Alcohol abuse (>3/day)
Contraindication MRI
Lactose intolerance
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL4822 |
| NTR-old | NTR5399 |
| Ander register | METC : 2014_200 |